TRIM9
| Gene Symbol | TRIM9 |
|---|---|
| Entrez Gene | 114088 |
| Alt Symbol | RNF91, SPRING |
| Species | Human |
| Gene Type | protein-coding |
| Description | tripartite motif containing 9 |
| Other Description | E3 ubiquitin-protein ligase TRIM9|RING finger protein 91|homolog of rat RING finger Spring|tripartite motif-containing 9|tripartite motif-containing protein 9 |
| Swissprots | Q9C027 D3DSB7 Q96D24 Q9C025 Q92557 Q96NI4 D3DSB8 Q9C026 |
| Accessions | EAW65680 EAW65681 EAW65682 EAW65683 EAW65684 Q9C026 AK054781 AK055388 BAB70913 BC013414 AAH13414 BC063872 AAH63872 BF966522 D87458 BAA13398 DA101991 DA173440 T77638 XM_005267301 XP_005267358 XM_005267302 XP_005267359 XM_006720018 XP_006720081 XM_011536389 XP_011534691 XM_011536390 XP_011534692 XM_011536391 XP_011534693 XM_011536392 XP_011534694 NM_015163 NP_055978 NM_052978 NP_443210 |
| Function | E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000269|PubMed:20085810}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20085810}. Cell projection, dendrite {ECO:0000269|PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle- associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum. {ECO:0000250}. |
| Tissue Specificity | Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies. {ECO:0000269|PubMed:20085810}. |
TRIM9 CRISPR/Cas9 KO Plasmid (h) - sc-406644 from Santa Cruz Biotechnology
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TRIM9 HDR Plasmid (h) - sc-406644-HDR from Santa Cruz Biotechnology
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TRIM9 Double Nickase Plasmid (h) - sc-406644-NIC from Santa Cruz Biotechnology
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TRIM9 Double Nickase Plasmid (h2) - sc-406644-NIC-2 from Santa Cruz Biotechnology
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TRIM9 CRISPR Activation Plasmid (h) - sc-406644-ACT from Santa Cruz Biotechnology
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TRIM9 CRISPR Activation Plasmid (h2) - sc-406644-ACT-2 from Santa Cruz Biotechnology
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TRIM9 Lentiviral Activation Particles (h) - sc-406644-LAC from Santa Cruz Biotechnology
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TRIM9 Lentiviral Activation Particles (h2) - sc-406644-LAC-2 from Santa Cruz Biotechnology
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TRIM9 siRNA (h) - sc-92385 from Santa Cruz Biotechnology
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TRIM9 shRNA Plasmid (h) - sc-92385-SH from Santa Cruz Biotechnology
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TRIM9 shRNA (h) Lentiviral Particles - sc-92385-V from Santa Cruz Biotechnology
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TRIM9 RNAi - H00114088-R02 from Novus Biologicals
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MISSION® esiRNA - EHU068511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22022 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22022 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11001 from Sigma-Aldrich
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TRIM9 siRNA (Human) - CRJ4348 from Cohesion Biosciences
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TRIM9 RNAi - H00114088-R01 from Novus Biologicals
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TRIM9 - MBS8238659 from MyBioSource
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shRNA set against Human TRIM9(NM_052978.4) - SHL095754 from Creative biogene
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TRIM9 shRNA Plasmid (Human) - CHJ4348 from Cohesion Biosciences
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TRIM9 miRNA 3'UTR clone - MiUTR1H-10764 from Creative biogene
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TRIM9 miRNA 3'UTR clone - MiUTR4H-TG09341 from Creative biogene
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