HAND1

Gene Symbol HAND1
Entrez Gene 9421
Alt Symbol Hxt, Thing1, bHLHa27, eHand
Species Human
Gene Type protein-coding
Description heart and neural crest derivatives expressed 1
Other Description class A basic helix-loop-helix protein 27|extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1|heart- and neural crest derivatives-expressed protein 1
Swissprots O96004
Accessions AAD19283 EAW61636 O96004 AF061756 AAD19280 BC021190 AAH21190 EU446688 ABZ92217 XM_005268531 XP_005268588 NM_004821 NP_004812
Function Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box) (By similarity). {ECO:0000250}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). {ECO:0000250}.
Tissue Specificity Heart.
Top Pathways Signaling pathways regulating pluripotency of stem cells

eHAND (D-1) - sc-390651 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
eHAND (D-1): sc-390651. Western blot analysis of eHAND expression in non-transfected: sc-117752 (A) and human eHAND transfected: sc-110104 (B) 293T whole cell lysates.

eHAND (E-10) - sc-374296 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
eHAND (E-10): sc-374296. Western blot analysis of eHAND expression in non-transfected: sc-117752 (A) and human eHAND transfected: sc-110104 (B) 293T whole cell lysates.

eHAND (F-7) - sc-390376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
eHAND (F-7): sc-390376. Western blot analysis of eHAND expression in non-transfected: sc-117752 (A) and human eHAND transfected: sc-110104 (B) 293T whole cell lysates.

eHAND (H-100) - sc-22817 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

eHAND (C-19) - sc-9413 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
eHAND (C-19): sc-9413. Western blot analysis of eHAND expression in non-transfected: sc-117752 (A) and human eHAND transfected: sc-110104 (B) 293T whole cell lysates.

eHAND (N-18) - sc-9412 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
eHAND (N-18): sc-9412. Western blot analysis of eHAND expression in non-transfected: sc-117750 (A) and human eHAND transfected: sc-110104 (B) whole cell lysates.

Anti-HAND1 antibody - ab115256 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Heart (formalin-fixed, paraffin-embedded) stained with ab115256 at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-HAND1 antibody - ab46822 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HAND1 antibody (ab46822) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-HAND1 antibody - ab196622 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorscence analysis of A459 cells labeling HAND1 with ab196622 at a 1/100 dilution. Right image treated with synthesized peptide.

Anti-HAND1 antibody - ab104320 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HAND1 antibody (ab104320) at 1 µg/ml + Human fetal liver lysate at 10 µg

Anti-HAND1 antibody - ab86009 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HAND1 antibody (ab86009) at 1/1000 dilutionLane 1 : Uninduced cultureLane 2 : Induced culture of E.coli Secondaryanti-Rabbit IgG HRP at 1/1000 dilution

Anti-HAND1 antibody [8E7A11,8C2F4] - ab130203 from Abcam

Host Mouse
Clonality Monoclonal
Clone 8E7A11,8C2F4
Anti-HAND1 antibody [8E7A11,8C2F4] (ab130203) at 1/500 dilution + Truncated Trx-HAND1 recombinant protein

Anti-HAND1 Antibody (aa168-181) - LS-C23001 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HAND1 Antibody (aa141-190) - LS-C118745 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of A549 cells, using HAND1 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-HAND1 Antibody (aa76-105, PE) - LS-C236087 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HAND1 Antibody (C-Terminus, Biotin) - LS-C244589 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HAND1 Antibody (clone 8E7A11,8C2F4) - LS-C109121 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8E7A11,8C2F4
Western blot using HAND1 mouse monoclonal antibody against truncated Trx-HAND1 recombinant protein (1).

Anti-HAND1 Antibody (C-Terminus, PE) - LS-C244592 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HAND1 Antibody (C-Terminus, AP) - LS-C244588 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HAND1 Antibody (C-Terminus, FITC) - LS-C244591 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HAND1 Antibody (aa76-105, AP) - LS-C246729 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HAND1 Antibody (C-Terminus, APC) - LS-C244590 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HAND1 Antibody (aa35-84) - LS-C115972 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HAND1 antibody LS-C115972 Western blot of Fetal liver lysate.

Anti-HAND1 Antibody (aa76-105, Biotin) - LS-C246731 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HAND1 Antibody (aa76-105, APC) - LS-C246730 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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