HAND1

Gene Symbol HAND1
Entrez Gene 9421
Alt Symbol Hxt, Thing1, bHLHa27, eHand
Species Human
Gene Type protein-coding
Description heart and neural crest derivatives expressed 1
Other Description class A basic helix-loop-helix protein 27|extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1|heart- and neural crest derivatives-expressed protein 1
Swissprots O96004
Accessions AAD19283 EAW61636 O96004 AF061756 AAD19280 BC021190 AAH21190 EU446688 ABZ92217 XM_005268531 XP_005268588 NM_004821 NP_004812
Function Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box) (By similarity). {ECO:0000250}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). {ECO:0000250}.
Tissue Specificity Heart.
Top Pathways Signaling pathways regulating pluripotency of stem cells

eHAND CRISPR/Cas9 KO Plasmid (h) - sc-403311 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eHAND HDR Plasmid (h) - sc-403311-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eHAND Double Nickase Plasmid (h) - sc-403311-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eHAND Double Nickase Plasmid (h2) - sc-403311-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eHAND CRISPR Activation Plasmid (h) - sc-403311-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eHAND CRISPR Activation Plasmid (h2) - sc-403311-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eHAND Lentiviral Activation Particles (h) - sc-403311-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eHAND Lentiviral Activation Particles (h2) - sc-403311-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eHAND siRNA (h) - sc-37922 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eHAND shRNA Plasmid (h) - sc-37922-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eHAND shRNA (h) Lentiviral Particles - sc-37922-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HAND1 RNAi - H00009421-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU152461 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9862 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9862 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HAND1 siRNA (Human) - CRH6247 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HAND1 - MBS8216944 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Hand1 (NM_004821.2) - SHH310229 from Creative biogene

Category siRNA
Species Reactivities Human

Human HAND1 siRNA - orb266749 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HAND1 shRNA Plasmid (Human) - CHH6247 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HAND1 miRNA 3'UTR clone - MiUTR4H-TG04086 from Creative biogene

Species Reactivities Human
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