Gene Symbol | KRT8 |
---|---|
Entrez Gene | 3856 |
Alt Symbol | CARD2, CK-8, CK8, CYK8, K2C8, K8, KO |
Species | Human |
Gene Type | protein-coding |
Description | keratin 8, type II |
Other Description | cytokeratin 8|cytokeratin-8|keratin, type II cytoskeletal 8|type-II keratin Kb8 |
Swissprots | Q6P4C7 B0AZN5 Q6GMY0 A8K4H3 Q96J60 Q53GJ0 P05787 F8VXB4 Q14099 Q14716 Q6DHW5 Q14717 |
Accessions | AAA35763 CAA52916 EAW96651 EAW96652 EAW96653 EAW96654 P05787 AI150751 AK222941 BAD96661 AK290938 BAF83627 AK310257 AK315826 BAF98717 AM392826 CAL37704 AM392892 CAL37770 BC000654 AAH00654 BC008200 AAH08200 BC011373 AAH11373 BC063513 AAH63513 BC073760 AAH73760 BC075839 AAH75839 BE300986 BM854215 BX417476 CX166336 DA051933 DA825311 DQ892637 ABM83563 DQ895875 ABM86801 M26512 AAA51542 M26513 M34225 AAA35748 M77025 U76549 AAB18966 X12882 CAA31376 X74929 CAA52882 X98614 CAA67203 Z36777 NM_001256282 NP_001243211 NM_001256293 NP_001243222 NM_002273 NP_002264 NR_045962 |
Function | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10973561, ECO:0000269|PubMed:19188445}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus matrix {ECO:0000250}. |
Tissue Specificity | Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. {ECO:0000269|PubMed:10973561, ECO:0000269|PubMed:16000376}. |