LRRK2

Gene Symbol	LRRK2
Entrez Gene	120892
Alt Symbol	AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Species	Human
Gene Type	protein-coding
Description	leucine-rich repeat kinase 2
Other Description	augmented in rheumatoid arthritis 17|leucine-rich repeat serine/threonine-protein kinase 2
Swissprots	Q6ZS50 Q5S007 Q8NCX9 A6NJU2
Accessions	Q5S007 AK026776 AK122640 AK127729 AK131537 AL832453 AL834529 CAD39185 AY792511 AAV63975 BC117180 AAI17181 BM285390 BR000408 FAA00322 BU634341 BX640975 CAE45989 CN294292 XM_005268629 XP_005268686 XM_011537877 XP_011536179 XM_011537878 XP_011536180 XM_011537879 XP_011536181 XM_011537880 XP_011536182 XM_011537881 XP_011536183 XM_011537882 XP_011536184 NM_198578 NP_940980
Function	Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852}.
Subcellular Location	Membrane; Peripheral membrane protein. Cytoplasm. Perikaryon. Mitochondrion. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:24687852}; Peripheral membrane protein {ECO:0000269|PubMed:24687852}; Cytoplasmic side {ECO:0000269|PubMed:24687852}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Note=Predominantly associated with intracytoplasmic vesicular and membranous structures (By similarity). Localized in the cytoplasm and associated with cellular membrane structures. Predominantly associated with the mitochondrial outer membrane of the mitochondria. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of neuronal perikarya and dendritic and axonal p
Tissue Specificity	Expressed in the brain. Expressed in pyramidal neurons in all cortical laminae of the visual cortex, in neurons of the substantia nigra pars compacta and caudate putamen (at protein level). Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. {ECO:0000269|PubMed:15541308, ECO:0000269|PubMed:15541309, ECO:0000269|PubMed:16532471, ECO:0000269|PubMed:17120249}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LRRK2 ELISA Kit - LS-F7866 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.122 ng/ml Range 0.313 - 20 ng/ml

Rat LRRK2 ELISA Kit - LS-F9745 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 29 pg/ml Range 78.125 - 5000 pg/ml

Human LRRK2 ELISA Kit - abx152239 from Abbexa Category ELISA Kit Sensitivity 0.122 ng/ml Range 0.313 ng/ml - 20 ng/ml

Leucine Rich Repeat Kinase 2 (LRRK2), Human, ELISA Kit - SEH716Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.122ng/mL Range 0.312-20ng/mL

Leucine-rich repeat serine/threonine-protein kinase 2, LRRK2, Human, ELISA Kit - E1515h from ARP American Research Products Category ELISA Kit Prices $779.00 Sizes 96 t Range 0.156-10 ng/mL

Leucine Rich Repeat Kinase 2 (LRRK2), ELISA Kit - MBS2022296 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human LRRK2 is typically less than 0.122ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.312-20ng/mL

Leucine Rich Repeat Kinase 2 (LRRK2), ELISA Kit - MBS2019558 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 29pg/mL. Range 78.13-5000pg/mL

ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) - SEH716Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) - SEH716Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 29pg/mL. Range 78.13-5000pg/mL The standard curve concentrations used for the ELISA’s were 5000pg/mL, 2500pg/mL, 1250pg/mL, 625pg/mL, 312.5pg/mL, 156.25pg/mL, 78.13pg/mL

ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) - SEH716Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse LRRK2 ELISA Kit - LS-F17882 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Human LRRK2 ELISA Kit - LS-F17883 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Leucine Rich Repeat Kinase 2 (LRRK2), Human, ELISA Kit - DL-LRRK2-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human LRRK2 ELISA Kit - orb369331 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 0.313-20ng/mL Detection low threshold: 0.122ng/mL

LRRK2 - EKH3558 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

LRRK2 (Human) ELISA Kit - K4228 from Biovision Category ELISA Kit Prices $695.00 Sizes 100 assays

Human LRRK2 ELISA Kit - E022515 from Biobool Category ELISA Kit Sensitivity <0.094ng/ml

LRRK2 ELISA Kit (Human) (OKEH04209) - OKEH04209 from Aviva Systems Biology Category ELISA Kit Prices $596.00 Sizes 96 wells Sensitivity < 0.07 ng/mL Range 0.15 - 10 ng/mL

Human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) ELISA Kit - AE34974HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 33 pg/mL Range 78.1-5000 pg/mL

Leucine Rich Repeat Kinase 2 (LRRK2), ELISA Kit - MBS453890 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.122ng/mL Range 0.312-20ng/mL

Leucine-rich repeat serine/threonine-protein kinase 2, ELISA Kit - MBS2883833 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.078 ng/mL Range 0.15 ng/mL -10.0 ng/mL

LRRK2, ELISA Kit - MBS846704 from MyBioSource Category ELISA Kit Prices $825.00 Sizes 100 assays Sensitivity < 0.094 ng/ml Range 0.156-10 ng/ml

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