| Gene Symbol |
LRRK2
|
| Entrez Gene |
120892
|
| Alt Symbol |
AURA17, DARDARIN, PARK8, RIPK7, ROCO2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine-rich repeat kinase 2
|
| Other Description |
augmented in rheumatoid arthritis 17|leucine-rich repeat serine/threonine-protein kinase 2
|
| Swissprots |
Q6ZS50 Q5S007 Q8NCX9 A6NJU2
|
| Accessions |
Q5S007 AK026776 AK122640 AK127729 AK131537 AL832453 AL834529 CAD39185 AY792511 AAV63975 BC117180 AAI17181 BM285390 BR000408 FAA00322 BU634341 BX640975 CAE45989 CN294292 XM_005268629 XP_005268686 XM_011537877 XP_011536179 XM_011537878 XP_011536180 XM_011537879 XP_011536181 XM_011537880 XP_011536182 XM_011537881 XP_011536183 XM_011537882 XP_011536184 NM_198578 NP_940980
|
| Function |
Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852}.
|
| Subcellular Location |
Membrane; Peripheral membrane protein. Cytoplasm. Perikaryon. Mitochondrion. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:24687852}; Peripheral membrane protein {ECO:0000269|PubMed:24687852}; Cytoplasmic side {ECO:0000269|PubMed:24687852}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Note=Predominantly associated with intracytoplasmic vesicular and membranous structures (By similarity). Localized in the cytoplasm and associated with cellular membrane structures. Predominantly associated with the mitochondrial outer membrane of the mitochondria. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of neuronal perikarya and dendritic and axonal p
|
| Tissue Specificity |
Expressed in the brain. Expressed in pyramidal neurons in all cortical laminae of the visual cortex, in neurons of the substantia nigra pars compacta and caudate putamen (at protein level). Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. {ECO:0000269|PubMed:15541308, ECO:0000269|PubMed:15541309, ECO:0000269|PubMed:16532471, ECO:0000269|PubMed:17120249}.
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