SDHAF4

Gene Symbol SDHAF4
Entrez Gene 135154
Alt Symbol C6orf57, Sdh8
Species Human
Gene Type protein-coding
Description succinate dehydrogenase complex assembly factor 4
Other Description SDH assembly factor 4|UPF0369 protein C6orf57|succinate dehydrogenase assembly factor 4, mitochondrial
Swissprots E1P532 Q5VUM1
Accessions CAK32392 EAW48810 EAW48811 EAW48812 Q5VUM1 BC018085 AAH18085 BC104649 AAI04650 BG703280 CF597237 GQ129294 ACT64428 GQ129295 ACT64429 HQ448686 ADQ33164 NM_145267 NP_660310
Function Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). {ECO:0000250|UniProtKB:P38345, ECO:0000269|PubMed:24954416}.
Subcellular Location Mitochondrion matrix {ECO:0000250|UniProtKB:P38345}.

C6orf57 (C-19) - sc-242230 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

C6orf57 (S-19) - sc-242228 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C6orf57 (S-19): sc-242228. Western blot analysis of C6orf57 expression in U-937 whole cell lysate.

Anti-C6orf57 antibody - ab122196 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122196 at 1/25 dilution staining C6orf57 in Paraffin-embedded Human Duodenum tissue by Immunohistochemistry.

C6orf57 Antibody - NBP1-86324 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: C6orf57 Antibody [NBP1-86324] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

C6orf57 Polyclonal Antibody - bs-15249R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-15249R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-15249R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-15249R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-15249R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, Cy3 Conjugated - bs-15249R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, Cy5 Conjugated - bs-15249R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, Cy5.5 Conjugated - bs-15249R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, Cy7 Conjugated - bs-15249R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, FITC Conjugated - bs-15249R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, Biotin Conjugated - bs-15249R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, HRP Conjugated - bs-15249R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-C6orf57 antibody produced in rabbit - HPA031824 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-C6ORF57: <B>Cat. No. HPA031824</B>: Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Anti-C6orf57 (51-65) antibody produced in rabbit - SAB1103388 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human C6orf57 was separated on SDS-PAGE, blotted with Anti-C6orf57 (51-65) (<B>Cat. No. SAB1103388</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000<BR/>2. Antibody dilution 1:1,000 + C6orf57 immunizing peptide (human, 51-65)

Anti-C6ORF57 (aa 23-107) polyclonal antibody - DPABH-20492 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-C6orf57 (71-85) antibody produced in rabbit - SAB1103389 from Sigma-Aldrich

Prices $307.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human C6orf57 was separated on SDS-PAGE, blotted with Anti-C6orf57 (71-85) (<B>Cat. No. SAB1103389</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000<BR/>2. Antibody dilution 1:1,000 + C6orf57 immunizing peptide (human, 71-85)

C6orf57 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated - bs-15249R-A594 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated - bs-15249R-A680 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody, ALEXA FLUOR® 750 Conjugated - bs-15249R-A750 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody Cy3 Conjugated - C03216Cy3 from Signalway Antibody

Prices $409.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C6orf57 Polyclonal Antibody Cy5 Conjugated - C03216Cy5 from Signalway Antibody

Prices $409.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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