| Gene Symbol |
SDHAF4
|
| Entrez Gene |
135154
|
| Alt Symbol |
C6orf57, Sdh8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
succinate dehydrogenase complex assembly factor 4
|
| Other Description |
SDH assembly factor 4|UPF0369 protein C6orf57|succinate dehydrogenase assembly factor 4, mitochondrial
|
| Swissprots |
E1P532 Q5VUM1
|
| Accessions |
CAK32392 EAW48810 EAW48811 EAW48812 Q5VUM1 BC018085 AAH18085 BC104649 AAI04650 BG703280 CF597237 GQ129294 ACT64428 GQ129295 ACT64429 HQ448686 ADQ33164 NM_145267 NP_660310
|
| Function |
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). {ECO:0000250|UniProtKB:P38345, ECO:0000269|PubMed:24954416}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000250|UniProtKB:P38345}.
|
![Western Blot: C6orf57 Overexpression Lysate (Adult Normal) [NBL1-08533] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for C6orf57.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4257_C6orf57%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08533-img0002.jpg)