SDHAF4

Gene Symbol SDHAF4
Entrez Gene 135154
Alt Symbol C6orf57, Sdh8
Species Human
Gene Type protein-coding
Description succinate dehydrogenase complex assembly factor 4
Other Description SDH assembly factor 4|UPF0369 protein C6orf57|succinate dehydrogenase assembly factor 4, mitochondrial
Swissprots E1P532 Q5VUM1
Accessions CAK32392 EAW48810 EAW48811 EAW48812 Q5VUM1 BC018085 AAH18085 BC104649 AAI04650 BG703280 CF597237 GQ129294 ACT64428 GQ129295 ACT64429 HQ448686 ADQ33164 NM_145267 NP_660310
Function Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). {ECO:0000250|UniProtKB:P38345, ECO:0000269|PubMed:24954416}.
Subcellular Location Mitochondrion matrix {ECO:0000250|UniProtKB:P38345}.

C6orf57 CRISPR/Cas9 KO Plasmid (h) - sc-410301 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C6orf57 HDR Plasmid (h) - sc-410301-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C6orf57 Double Nickase Plasmid (h) - sc-410301-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C6orf57 Double Nickase Plasmid (h2) - sc-410301-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C6orf57 CRISPR Activation Plasmid (h) - sc-410301-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C6orf57 CRISPR Activation Plasmid (h2) - sc-410301-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C6orf57 Lentiviral Activation Particles (h) - sc-410301-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C6orf57 Lentiviral Activation Particles (h2) - sc-410301-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C6orf57 siRNA (h) - sc-95579 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C6orf57 shRNA Plasmid (h) - sc-95579-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C6orf57 shRNA (h) Lentiviral Particles - sc-95579-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU037011 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5066 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5066 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00234 from Sigma-Aldrich

Category miRNA

C6orf57 siRNA (Human) - CRJ5162 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C6orf57 - MBS8235327 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human C6orf57 (NM_145267.2) - SHH252321 from Creative biogene

Category siRNA
Species Reactivities Human

Human C6orf57 siRNA - orb275663 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C6orf57 shRNA Plasmid (Human) - CHJ5162 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

C6ORF57 miRNA 3'UTR clone - MiUTR1H-01472 from Creative biogene

Species Reactivities Human
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