Gene Symbol | MAST2 |
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Entrez Gene | 23139 |
Alt Symbol | MAST205, MTSSK |
Species | Human |
Gene Type | protein-coding |
Description | microtubule associated serine/threonine kinase 2 |
Other Description | microtubule associated testis specific serine/threonine protein kinase|microtubule-associated serine/threonine-protein kinase 2 |
Swissprots | Q8NDG1 Q5VT07 O94899 Q6P0Q8 Q9BYE8 Q96B94 Q5VT08 Q7LGC4 |
Accessions | EAX06948 EAX06949 Q6P0Q8 AB018350 BAA34527 AB047005 BAB40778 AK027123 AK055291 BAG51495 AK096519 BAG53313 AK309510 AL137594 CAB70833 AL540100 AL833919 CAD38775 BC006166 AAH06166 BC015816 AAH15816 BC065499 AAH65499 BM675011 CN297081 XM_005270652 XP_005270709 XM_005270654 XP_005270711 XM_005270655 XP_005270712 XM_005270656 XP_005270713 XM_006710475 XP_006710538 XM_006710477 XP_006710540 XM_011541059 XP_011539361 XM_011541060 XP_011539362 XM_011541061 XP_011539363 XM_011541062 XP_011539364 XM_011541063 XP_011539365 XM_011541064 XP_011539366 XM_011541065 XP_011539367 XM_011541066 XP_011539368 XM_011541067 XP_011539369 XM_011541068 XP_011539370 XM_011541069 XP_011539371 NM_015112 NP_055927 |
Function | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12117771}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to the sub-membranous area on interaction with CDHR2. |
Tissue Specificity | Abundant in the testis. {ECO:0000269|PubMed:8902215}. |
MAST205 CRISPR/Cas9 KO Plasmid (h) - sc-409835 from Santa Cruz Biotechnology
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MAST205 HDR Plasmid (h) - sc-409835-HDR from Santa Cruz Biotechnology
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MAST205 Double Nickase Plasmid (h) - sc-409835-NIC from Santa Cruz Biotechnology
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MAST205 Double Nickase Plasmid (h2) - sc-409835-NIC-2 from Santa Cruz Biotechnology
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MAST205 CRISPR Activation Plasmid (h) - sc-409835-ACT from Santa Cruz Biotechnology
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MAST205 CRISPR Activation Plasmid (h2) - sc-409835-ACT-2 from Santa Cruz Biotechnology
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MAST205 Lentiviral Activation Particles (h) - sc-409835-LAC from Santa Cruz Biotechnology
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MAST205 Lentiviral Activation Particles (h2) - sc-409835-LAC-2 from Santa Cruz Biotechnology
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MAST205 siRNA (h) - sc-62602 from Santa Cruz Biotechnology
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MAST205 shRNA Plasmid (h) - sc-62602-SH from Santa Cruz Biotechnology
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MAST205 shRNA (h) Lentiviral Particles - sc-62602-V from Santa Cruz Biotechnology
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MAST205 RNAi - H00023139-R03 from Novus Biologicals
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MISSION® esiRNA - EHU134721 from Sigma-Aldrich
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MISSION® siRNA - SIHK1259 from Sigma-Aldrich
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MISSION® siRNA - SIHK1260 from Sigma-Aldrich
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MISSION® siRNA - SIHK1258 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2405 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2405 from Sigma-Aldrich
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MAST2 siRNA (Human) - CRH8027 from Cohesion Biosciences
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shRNA set against Human MAST2 (NM_015112.2) - SHH338515 from Creative biogene
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shRNA set against Human MAST2(NM_015112.2) - SHH178301 from Creative biogene
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MAST2 shRNA Plasmid (Human) - CHH8027 from Cohesion Biosciences
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MAST2 miRNA 3'UTR clone - MiUTR1H-06116 from Creative biogene
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