| Gene Symbol |
DNAJC27
|
| Entrez Gene |
51277
|
| Alt Symbol |
RBJ, RabJS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DnaJ (Hsp40) homolog, subfamily C, member 27
|
| Other Description |
Ras-associated protein Rap1|dnaJ homolog subfamily C member 27|rab and DnaJ domain-containing protein
|
| Swissprots |
Q5JV88 Q86Y24 Q9NZQ0
|
| Accessions |
AAX93052 AAY14788 EAX00735 EAX00736 EAX00737 EAX00738 Q9NZQ0 AF178983 AAF44347 AK294726 BAG57873 AL117490 AL137731 CAI46214 AY094594 AAM22521 BC034049 AAH34049 BK001284 DAA01323 XM_011532902 XP_011531204 XR_244938 NM_001198559 NP_001185488 NM_016544 NP_057628
|
| Function |
GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. {ECO:0000250|UniProtKB:Q8CFP6}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:Q8CFP6}.
|
| Tissue Specificity |
Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers. {ECO:0000269|PubMed:24746703}.
|