Gene Symbol | DNAJC27 |
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Entrez Gene | 51277 |
Alt Symbol | RBJ, RabJS |
Species | Human |
Gene Type | protein-coding |
Description | DnaJ (Hsp40) homolog, subfamily C, member 27 |
Other Description | Ras-associated protein Rap1|dnaJ homolog subfamily C member 27|rab and DnaJ domain-containing protein |
Swissprots | Q5JV88 Q86Y24 Q9NZQ0 |
Accessions | AAX93052 AAY14788 EAX00735 EAX00736 EAX00737 EAX00738 Q9NZQ0 AF178983 AAF44347 AK294726 BAG57873 AL117490 AL137731 CAI46214 AY094594 AAM22521 BC034049 AAH34049 BK001284 DAA01323 XM_011532902 XP_011531204 XR_244938 NM_001198559 NP_001185488 NM_016544 NP_057628 |
Function | GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. {ECO:0000250|UniProtKB:Q8CFP6}. |
Subcellular Location | Nucleus {ECO:0000250|UniProtKB:Q8CFP6}. |
Tissue Specificity | Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers. {ECO:0000269|PubMed:24746703}. |
RBJ CRISPR/Cas9 KO Plasmid (h) - sc-409933 from Santa Cruz Biotechnology
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RBJ HDR Plasmid (h) - sc-409933-HDR from Santa Cruz Biotechnology
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RBJ Double Nickase Plasmid (h) - sc-409933-NIC from Santa Cruz Biotechnology
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RBJ Double Nickase Plasmid (h2) - sc-409933-NIC-2 from Santa Cruz Biotechnology
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RBJ CRISPR Activation Plasmid (h) - sc-409933-ACT from Santa Cruz Biotechnology
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RBJ CRISPR Activation Plasmid (h2) - sc-409933-ACT-2 from Santa Cruz Biotechnology
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RBJ Lentiviral Activation Particles (h) - sc-409933-LAC from Santa Cruz Biotechnology
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RBJ Lentiviral Activation Particles (h2) - sc-409933-LAC-2 from Santa Cruz Biotechnology
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RBJ siRNA (h) - sc-94951 from Santa Cruz Biotechnology
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RBJ shRNA Plasmid (h) - sc-94951-SH from Santa Cruz Biotechnology
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RBJ shRNA (h) Lentiviral Particles - sc-94951-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU008771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7374 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7374 from Sigma-Aldrich
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DNAJC27 siRNA (Human) - CRH9655 from Cohesion Biosciences
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DNAJC27 - MBS8219161 from MyBioSource
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shRNA set against Human DNAJC27 (NM_016544.2) - SHH279605 from Creative biogene
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DNAJC27 shRNA Plasmid (Human) - CHH9655 from Cohesion Biosciences
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DNAJC27 miRNA 3'UTR clone - MiUTR4H-TG02805 from Creative biogene
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