Gene Symbol | EIF3H |
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Entrez Gene | 8667 |
Alt Symbol | EIF3S3, eIF3-gamma, eIF3-p40 |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation initiation factor 3, subunit H |
Other Description | eIF-3-gamma|eIF3 p40 subunit|eukaryotic translation initiation factor 3 subunit 3|eukaryotic translation initiation factor 3 subunit H|eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)|eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)|eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa |
Swissprots | O15372 |
Accessions | AAC84044 EAW91956 EAW91957 EAW91958 EAW91959 O15372 AA902770 AK093128 BAG52660 AK222520 BAD96240 AK222620 BAD96340 AK296162 BAG58901 AU117206 BC000386 AAH00386 BC090880 AAH90880 BT019594 AAV38401 CR456906 CAG33187 U54559 AAD03465 NM_003756 NP_003747 |
Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}. |
Top Pathways | RNA transport, Measles |
eIF3H (D9C1) XP ® Rabbit mAb - 3413 from Cell Signaling Technology
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eIF3γ (E-10) - sc-271283 from Santa Cruz Biotechnology
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eIF3γ (H-302) - sc-50355 from Santa Cruz Biotechnology
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eIF3γ (N-20) - sc-16359 from Santa Cruz Biotechnology
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Anti-EIF3S3 antibody - ab37648 from Abcam
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Anti-EIF3S3 antibody - N-terminal - ab171419 from Abcam
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Anti-EIF3H / EIF3S3 Antibody (aa70-99, Azide-free, HRP) - LS-C213743 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (clone 3C6) - LS-C139375 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa152-251) - LS-C307372 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa69-99) - LS-C321071 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (N-Terminus) - LS-C81554 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa246-295) - LS-C81555 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody - LS-C346190 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa302-352) - LS-C288536 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa152-251, clone 10C172, Azide-free) - LS-C183608 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa70-99, AP) - LS-C213737 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa70-99, APC) - LS-C213738 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa70-99, FITC) - LS-C213739 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa70-99, Biotin) - LS-C213740 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa70-99, PE) - LS-C213742 from LifeSpan Bioscience
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Anti-EIF3H / EIF3S3 Antibody (aa70-99) - LS-C167691 from LifeSpan Bioscience
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EIF3S3 Antibody - NBP1-84870 from Novus Biologicals
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EIF3S3 Antibody - NBP1-84871 from Novus Biologicals
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EIF3S3 Antibody (3B12) - H00008667-M01 from Novus Biologicals
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EIF3S3 Antibody - NBP1-31572 from Novus Biologicals
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