Gene Symbol | EIF3H |
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Entrez Gene | 8667 |
Alt Symbol | EIF3S3, eIF3-gamma, eIF3-p40 |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation initiation factor 3, subunit H |
Other Description | eIF-3-gamma|eIF3 p40 subunit|eukaryotic translation initiation factor 3 subunit 3|eukaryotic translation initiation factor 3 subunit H|eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)|eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)|eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa |
Swissprots | O15372 |
Accessions | AAC84044 EAW91956 EAW91957 EAW91958 EAW91959 O15372 AA902770 AK093128 BAG52660 AK222520 BAD96240 AK222620 BAD96340 AK296162 BAG58901 AU117206 BC000386 AAH00386 BC090880 AAH90880 BT019594 AAV38401 CR456906 CAG33187 U54559 AAD03465 NM_003756 NP_003747 |
Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}. |
Top Pathways | RNA transport, Measles |
eIF3γ CRISPR/Cas9 KO Plasmid (h) - sc-418339 from Santa Cruz Biotechnology
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eIF3γ HDR Plasmid (h) - sc-418339-HDR from Santa Cruz Biotechnology
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eIF3γ Double Nickase Plasmid (h) - sc-418339-NIC from Santa Cruz Biotechnology
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eIF3γ Double Nickase Plasmid (h2) - sc-418339-NIC-2 from Santa Cruz Biotechnology
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eIF3γ CRISPR Activation Plasmid (h) - sc-418339-ACT from Santa Cruz Biotechnology
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eIF3γ CRISPR Activation Plasmid (h2) - sc-418339-ACT-2 from Santa Cruz Biotechnology
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eIF3γ Lentiviral Activation Particles (h) - sc-418339-LAC from Santa Cruz Biotechnology
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eIF3γ Lentiviral Activation Particles (h2) - sc-418339-LAC-2 from Santa Cruz Biotechnology
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eIF3γ siRNA (h) - sc-40549 from Santa Cruz Biotechnology
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eIF3γ shRNA Plasmid (h) - sc-40549-SH from Santa Cruz Biotechnology
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eIF3γ shRNA (h) Lentiviral Particles - sc-40549-V from Santa Cruz Biotechnology
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EIF3S3 RNAi - H00008667-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN7764 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7764 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01152 from Sigma-Aldrich
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EIF3H siRNA (Human) - CRH5702 from Cohesion Biosciences
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EIF3H - MBS8215476 from MyBioSource
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shRNA set against Human EIF3H (NM_003756.2) - SHH284513 from Creative biogene
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shRNA set against Human EIF3S3(NM_003756.2) - SHH029243 from Creative biogene
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Human EIF3H siRNA - orb266204 from Biorbyt
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EIF3H shRNA Plasmid (Human) - CHH5702 from Cohesion Biosciences
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EIF3H miRNA 3'UTR clone - MiUTR1H-03165 from Creative biogene
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