| Gene Symbol |
EIF3H
|
| Entrez Gene |
8667
|
| Alt Symbol |
EIF3S3, eIF3-gamma, eIF3-p40
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 3, subunit H
|
| Other Description |
eIF-3-gamma|eIF3 p40 subunit|eukaryotic translation initiation factor 3 subunit 3|eukaryotic translation initiation factor 3 subunit H|eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)|eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)|eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa
|
| Swissprots |
O15372
|
| Accessions |
AAC84044 EAW91956 EAW91957 EAW91958 EAW91959 O15372 AA902770 AK093128 BAG52660 AK222520 BAD96240 AK222620 BAD96340 AK296162 BAG58901 AU117206 BC000386 AAH00386 BC090880 AAH90880 BT019594 AAV38401 CR456906 CAG33187 U54559 AAD03465 NM_003756 NP_003747
|
| Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
|
| Top Pathways |
RNA transport, Measles
|
