| Gene Symbol |
MGAT4C
|
| Entrez Gene |
25834
|
| Alt Symbol |
GNTIVH, HGNT-IV-H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MGAT4 family, member C
|
| Other Description |
N-acetylglucosaminyltransferase IV homolog|N-acetylglucosaminyltransferase IVc|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc|UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc|UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV|UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homolog|alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C|glcNAc-T IVc|gnT-IVc|mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
|
| Swissprots |
B4DRH2 Q9UBM8 Q9UIU5 Q4G199
|
| Accessions |
BAA83087 EAW97402 Q9UBM8 AK127727 BAG54560 AK299253 BAG61284 BC026068 AAH26068 BC035851 BC064141 AAH64141 BI667691 DA795621 HG505047 XM_005268776 XP_005268833 XM_005268779 XP_005268836 XM_011538149 XP_011536451 XM_011538150 XP_011536452 XM_011538151 XP_011536453 XM_011538152 XP_011536454 XM_011538153 XP_011536455 XM_011538154 XP_011536456 XM_011538155 XP_011536457 XM_011538156 XP_011536458 XM_011538157 XP_011536459 XM_011538158 XP_011536460 XM_011538159 XP_011536461 XM_011538160 XP_011536462 NM_013244 NP_037376
|
| Function |
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). {ECO:0000250, ECO:0000269|PubMed:10962001}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, adrenal gland, testis, liver, brain and fetal brain. Not expressed in pancreas. {ECO:0000269|PubMed:10570912}.
|
| Top Pathways |
N-Glycan biosynthesis
|