Gene Symbol | MGAT4C |
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Entrez Gene | 25834 |
Alt Symbol | GNTIVH, HGNT-IV-H |
Species | Human |
Gene Type | protein-coding |
Description | MGAT4 family, member C |
Other Description | N-acetylglucosaminyltransferase IV homolog|N-acetylglucosaminyltransferase IVc|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc|UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc|UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV|UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homolog|alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C|glcNAc-T IVc|gnT-IVc|mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) |
Swissprots | B4DRH2 Q9UBM8 Q9UIU5 Q4G199 |
Accessions | BAA83087 EAW97402 Q9UBM8 AK127727 BAG54560 AK299253 BAG61284 BC026068 AAH26068 BC035851 BC064141 AAH64141 BI667691 DA795621 HG505047 XM_005268776 XP_005268833 XM_005268779 XP_005268836 XM_011538149 XP_011536451 XM_011538150 XP_011536452 XM_011538151 XP_011536453 XM_011538152 XP_011536454 XM_011538153 XP_011536455 XM_011538154 XP_011536456 XM_011538155 XP_011536457 XM_011538156 XP_011536458 XM_011538157 XP_011536459 XM_011538158 XP_011536460 XM_011538159 XP_011536461 XM_011538160 XP_011536462 NM_013244 NP_037376 |
Function | Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). {ECO:0000250, ECO:0000269|PubMed:10962001}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in heart, adrenal gland, testis, liver, brain and fetal brain. Not expressed in pancreas. {ECO:0000269|PubMed:10570912}. |
Top Pathways | N-Glycan biosynthesis |
GnT-IVH CRISPR/Cas9 KO Plasmid (h) - sc-418372 from Santa Cruz Biotechnology
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GnT-IVH HDR Plasmid (h) - sc-418372-HDR from Santa Cruz Biotechnology
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GnT-IVH Double Nickase Plasmid (h) - sc-418372-NIC from Santa Cruz Biotechnology
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GnT-IVH Double Nickase Plasmid (h2) - sc-418372-NIC-2 from Santa Cruz Biotechnology
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GnT-IVH CRISPR Activation Plasmid (h) - sc-418372-ACT from Santa Cruz Biotechnology
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GnT-IVH CRISPR Activation Plasmid (h2) - sc-418372-ACT-2 from Santa Cruz Biotechnology
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GnT-IVH Lentiviral Activation Particles (h) - sc-418372-LAC from Santa Cruz Biotechnology
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GnT-IVH Lentiviral Activation Particles (h2) - sc-418372-LAC-2 from Santa Cruz Biotechnology
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GnT-IVH siRNA (h) - sc-96198 from Santa Cruz Biotechnology
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GnT-IVH shRNA Plasmid (h) - sc-96198-SH from Santa Cruz Biotechnology
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GnT-IVH shRNA (h) Lentiviral Particles - sc-96198-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU054971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13277 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13277 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04767 from Sigma-Aldrich
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MGAT4C siRNA (Human) - CRH8531 from Cohesion Biosciences
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shRNA set against Human MGAT4C (NM_013244.3) - SHH341399 from Creative biogene
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MGAT4C shRNA Plasmid (Human) - CHH8531 from Cohesion Biosciences
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MGAT4C miRNA 3'UTR clone - MiUTR1H-06245 from Creative biogene
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