Gene Symbol | BTG2 |
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Entrez Gene | 7832 |
Alt Symbol | PC3, TIS21 |
Species | Human |
Gene Type | protein-coding |
Description | BTG family, member 2 |
Other Description | B-cell translocation gene 2|NGF-inducible anti-proliferative protein PC3|nerve growth factor-inducible anti-proliferative|pheochromacytoma cell-3|protein BTG2 |
Swissprots | P78543 Q5VUT0 Q3KR25 A0A024R986 |
Accessions | AAL05626 EAW91475 EAW91476 P78543 BC105948 AAI05949 BC105949 AAI05950 EU446924 ABZ92453 U72649 AAB37580 Y09943 CAA71074 NM_006763 NP_006754 |
Function | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:18337750, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:23236473}. |
Top Pathways | RNA degradation |
BTG2 CRISPR/Cas9 KO Plasmid (h) - sc-401022 from Santa Cruz Biotechnology
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BTG2 HDR Plasmid (h) - sc-401022-HDR from Santa Cruz Biotechnology
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BTG2 Double Nickase Plasmid (h) - sc-401022-NIC from Santa Cruz Biotechnology
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BTG2 Double Nickase Plasmid (h2) - sc-401022-NIC-2 from Santa Cruz Biotechnology
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BTG2 CRISPR Activation Plasmid (h) - sc-401022-ACT from Santa Cruz Biotechnology
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BTG2 CRISPR Activation Plasmid (h2) - sc-401022-ACT-2 from Santa Cruz Biotechnology
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BTG2 Lentiviral Activation Particles (h) - sc-401022-LAC from Santa Cruz Biotechnology
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BTG2 Lentiviral Activation Particles (h2) - sc-401022-LAC-2 from Santa Cruz Biotechnology
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BTG2 siRNA (h) - sc-43645 from Santa Cruz Biotechnology
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BTG2 shRNA Plasmid (h) - sc-43645-SH from Santa Cruz Biotechnology
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BTG2 shRNA (h) Lentiviral Particles - sc-43645-V from Santa Cruz Biotechnology
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BTG2 RNAi - H00007832-R01 from Novus Biologicals
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MISSION® esiRNA - EHU048061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4104 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4104 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12876 from Sigma-Aldrich
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BTG2 siRNA (Human) - CRH5287 from Cohesion Biosciences
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BTG2 - MBS8200441 from MyBioSource
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shRNA set against Human BTG2 (NM_006763.2) - SHH248258 from Creative biogene
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shRNA set against Human BTG2(NM_006763.2) - SHG107533 from Creative biogene
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Human BTG2 siRNA - orb265789 from Biorbyt
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BTG2 shRNA Plasmid (Human) - CHH5287 from Cohesion Biosciences
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BTG2 miRNA 3'UTR clone - MiUTR1H-00979 from Creative biogene
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