| Gene Symbol |
PODXL2
|
| Entrez Gene |
50512
|
| Alt Symbol |
EG, PODLX2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
podocalyxin-like 2
|
| Other Description |
endoglycan|podocalyxin-like protein 2
|
| Swissprots |
Q8WUV6 Q6UVY4 Q9NZ53
|
| Accessions |
EAW79337 EAW79338 Q9NZ53 AF219137 AAF44629 AL524055 AY359096 AAQ89454 BC019330 AAH19330 BC052585 AAH52585 DB543702 NM_015720 NP_056535
|
| Function |
Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins. {ECO:0000269|PubMed:18606703}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells. {ECO:0000269|PubMed:10722749, ECO:0000269|PubMed:18606703}.
|
![Western Blot: PODXL2 Overexpression Lysate (Adult Normal) [NBL1-14563] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PODXL2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6700_PODXL2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14563-img0002.jpg)