Gene Symbol | PODXL2 |
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Entrez Gene | 50512 |
Alt Symbol | EG, PODLX2 |
Species | Human |
Gene Type | protein-coding |
Description | podocalyxin-like 2 |
Other Description | endoglycan|podocalyxin-like protein 2 |
Swissprots | Q8WUV6 Q6UVY4 Q9NZ53 |
Accessions | EAW79337 EAW79338 Q9NZ53 AF219137 AAF44629 AL524055 AY359096 AAQ89454 BC019330 AAH19330 BC052585 AAH52585 DB543702 NM_015720 NP_056535 |
Function | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins. {ECO:0000269|PubMed:18606703}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells. {ECO:0000269|PubMed:10722749, ECO:0000269|PubMed:18606703}. |
Endoglycan CRISPR/Cas9 KO Plasmid (h) - sc-409915 from Santa Cruz Biotechnology
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Endoglycan HDR Plasmid (h) - sc-409915-HDR from Santa Cruz Biotechnology
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Endoglycan Double Nickase Plasmid (h) - sc-409915-NIC from Santa Cruz Biotechnology
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Endoglycan Double Nickase Plasmid (h2) - sc-409915-NIC-2 from Santa Cruz Biotechnology
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Endoglycan CRISPR Activation Plasmid (h) - sc-409915-ACT from Santa Cruz Biotechnology
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Endoglycan CRISPR Activation Plasmid (h2) - sc-409915-ACT-2 from Santa Cruz Biotechnology
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Endoglycan Lentiviral Activation Particles (h) - sc-409915-LAC from Santa Cruz Biotechnology
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Endoglycan Lentiviral Activation Particles (h2) - sc-409915-LAC-2 from Santa Cruz Biotechnology
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Endoglycan siRNA (h) - sc-72322 from Santa Cruz Biotechnology
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Endoglycan shRNA Plasmid (h) - sc-72322-SH from Santa Cruz Biotechnology
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Endoglycan shRNA (h) Lentiviral Particles - sc-72322-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU146331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17080 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17080 from Sigma-Aldrich
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PODXL2 siRNA (Human) - CRH9381 from Cohesion Biosciences
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shRNA set against Human PODXL2 (NM_015720.3) - SHH378976 from Creative biogene
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Human PODXL2 siRNA - orb269883 from Biorbyt
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PODXL2 shRNA Plasmid (Human) - CHH9381 from Cohesion Biosciences
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PODXL2 miRNA 3'UTR clone - MiUTR3H-15739 from Creative biogene
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