ATG13

Gene Symbol	ATG13
Entrez Gene	9776
Alt Symbol	KIAA0652, PARATARG8
Species	Human
Gene Type	protein-coding
Description	autophagy related 13
Other Description	ATG13 autophagy related 13 homolog|autophagy-related protein 13
Swissprots	Q9BRL3 B4DFI4 Q9H8B0 D3DQQ2 D3DQQ1 E9PQZ8 Q53EN6 O75143
Accessions	EAW67985 EAW67986 EAW67987 EAW67988 EAW67989 EAW67990 EAW67991 O75143 AB014552 BAA31627 AF052175 AK000705 AK023867 BAB14707 AK223603 BAD97323 AK289641 BAF82330 AK293109 BAF85798 AK294110 BAG57445 AK296526 BAG59157 AK315925 BAH14296 BC001331 AAH01331 BC002378 AAH02378 BC006191 AAH06191 CD675643 DA195671 GQ129361 ACT64495 GQ129362 ACT64496 HQ448260 ADQ32740 XM_005253262 XP_005253319 XM_005253263 XP_005253320 XM_005253265 XP_005253322 XM_005253266 XP_005253323 XM_005253268 XP_005253325 XM_006718394 XP_006718457 XM_006718395 XP_006718458 XM_006718396 XP_006718459 XM_011520493 XP_011518795 XM_011520494 XP_011518796 XM_011520495 XP_011518797 XM_011520496 XP_011518798 XM_011520497 XP_011518799 XM_011520498 XP_011518800 XM_011520499 XP_011518801 XM_011520500 XP_011518802 XM_011520501 XP_011518803 XM_011520502 XP_011518804 XM_011520503 XP_011518805 NM_001142673 NP_001136145 NM_001205119 NP_001192048 NM_001205120 NP_001192049 NM_001205121 NP_001192050 NM_001205122 NP_001192051 NM_014741 NP_055556
Function	Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000250}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Atg13 siRNA I - 12043 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Atg13 CRISPR/Cas9 KO Plasmid (h) - sc-404702 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg13 HDR Plasmid (h) - sc-404702-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KIAA0652 Double Nickase Plasmid (h) - sc-404702-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg13 Double Nickase Plasmid (h2) - sc-404702-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KIAA0652 CRISPR Activation Plasmid (h) - sc-404702-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg13 CRISPR Activation Plasmid (h2) - sc-404702-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

KIAA0652 Lentiviral Activation Particles (h) - sc-404702-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg13 Lentiviral Activation Particles (h2) - sc-404702-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg13 siRNA (h) - sc-97013 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Atg13 shRNA Plasmid (h) - sc-97013-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HARBI1 siRNA (h) - sc-97003 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HARBI1 shRNA Plasmid (h) - sc-97003-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HARBI1 shRNA (h) Lentiviral Particles - sc-97003-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU158391 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3644 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3644 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11265 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11265

ATG13 siRNA (Human) - CRH6538 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATG13 - MBS8232279 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ATG13 (NM_014741.4) - SHH242038 from Creative biogene Category siRNA Species Reactivities Human

Human ATG13 siRNA - orb267040 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATG13 shRNA Plasmid (Human) - CHH6538 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ATG13 miRNA 3'UTR clone - MiUTR4H-TG10637 from Creative biogene Species Reactivities Human

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