| Gene Symbol |
RNASET2
|
| Entrez Gene |
8635
|
| Alt Symbol |
RNASE6PL, bA514O12.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribonuclease T2
|
| Other Description |
ribonuclease 6
|
| Swissprots |
Q9BZ46 Q8TCU2 E1P5C3 O00584 Q5T8Q0 B2RDA7 Q9BZ47
|
| Accessions |
EAW47511 EAW47512 EAW47513 EAW47514 EAW47515 EAW47516 EAW47517 EAW47518 EAW47519 O00584 AJ419865 CAD12030 AJ419866 CAD12031 AJ419867 CAD12032 AK001769 AK124363 AK315467 BAG37854 BC001660 AAH01660 BC001819 AAH01819 BC019871 BC036282 BC039713 AAH39713 BC041056 BC051912 AAH51912 CB130245 U85625 AAC51363 NM_003730 NP_003721
|
| Function |
Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism. {ECO:0000250, ECO:0000269|PubMed:16620762, ECO:0000269|PubMed:19525954, ECO:0000269|PubMed:22735700}.
|
| Subcellular Location |
Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.
|
| Tissue Specificity |
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain. {ECO:0000269|PubMed:19525954}.
|
![Western Blot: RNASET2 Overexpression Lysate (Adult Normal) [NBP2-07960] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNASET2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10179_RNASET2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07960-img0001.jpg)