Gene Symbol | SCAI |
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Entrez Gene | 286205 |
Alt Symbol | C9orf126, NET40 |
Species | Human |
Gene Type | protein-coding |
Description | suppressor of cancer cell invasion |
Other Description | protein SCAI|suppressor of cancer cell invasion protein |
Swissprots | Q8N1I4 Q5T163 Q3SXZ1 Q8N9R8 Q3SXZ2 |
Accessions | EAW87608 EAW87609 Q8N9R8 AF086497 AK021820 AK093983 AK098024 BAC05217 BC029431 BC037940 BC104030 AAI04031 BC104031 AAI04032 BC104032 AAI04033 BM873972 DB048788 XR_929767 XR_929768 NM_001144877 NP_001138349 NM_173690 NP_775961 |
Function | Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. {ECO:0000269|PubMed:19350017}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:19350017}. Cytoplasm {ECO:0000269|PubMed:19350017}. Note=Nuclear localization is required for inhibition of MKL1. {ECO:0000250}. |
SCAI CRISPR/Cas9 KO Plasmid (h) - sc-409513 from Santa Cruz Biotechnology
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SCAI HDR Plasmid (h) - sc-409513-HDR from Santa Cruz Biotechnology
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SCAI Double Nickase Plasmid (h) - sc-409513-NIC from Santa Cruz Biotechnology
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SCAI Double Nickase Plasmid (h2) - sc-409513-NIC-2 from Santa Cruz Biotechnology
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SCAI CRISPR Activation Plasmid (h) - sc-409513-ACT from Santa Cruz Biotechnology
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SCAI CRISPR Activation Plasmid (h2) - sc-409513-ACT-2 from Santa Cruz Biotechnology
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SCAI Lentiviral Activation Particles (h) - sc-409513-LAC from Santa Cruz Biotechnology
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SCAI Lentiviral Activation Particles (h2) - sc-409513-LAC-2 from Santa Cruz Biotechnology
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SCAI siRNA (h) - sc-92937 from Santa Cruz Biotechnology
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SCAI shRNA Plasmid (h) - sc-92937-SH from Santa Cruz Biotechnology
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SCAI shRNA (h) Lentiviral Particles - sc-92937-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU016901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18881 from Sigma-Aldrich
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SCAI siRNA (Human) - CRJ7158 from Cohesion Biosciences
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SCAI - MBS8202527 from MyBioSource
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shRNA set against Human SCAI (NM_173690.4) - SHH402265 from Creative biogene
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SCAI shRNA Plasmid (Human) - CHJ7158 from Cohesion Biosciences
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SCAI miRNA 3'UTR clone - MiUTR4H-TG07811 from Creative biogene
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