| Gene Symbol |
PLXND1
|
| Entrez Gene |
23129
|
| Alt Symbol |
PLEXD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin D1
|
| Other Description |
plexin-D1
|
| Swissprots |
Q6PJS9 C9JPZ6 Q9BTQ2 Q9Y4D7 Q8IZJ2 A7E2C6
|
| Accessions |
EAW79238 EAW79239 EAW79240 Q9Y4D7 AB014520 BAA31595 AK026388 AK299425 BAG61405 AY116661 AAM49063 BC003526 AAH03526 BC011848 AAH11848 BC030110 BC044228 AAH44228 BC062465 AAH62465 BC150280 AAI50281 BU527983 CX761094 XM_011512588 XP_011510890 XM_011512589 XP_011510891 XM_011512590 XP_011510892 XM_011512591 XP_011510893 XM_011512592 XP_011510894 XR_924116 NM_015103 NP_055918
|
| Function |
Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. {ECO:0000250, ECO:0000269|PubMed:20385769}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes. {ECO:0000269|PubMed:12412018}.
|