TNFRSF10A

Gene Symbol	TNFRSF10A
Entrez Gene	8797
Alt Symbol	APO2, CD261, DR4, TRAILR-1, TRAILR1
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 10a
Other Description	TNF-related apoptosis-inducing ligand receptor 1|TRAIL receptor 1|TRAIL-R1|cytotoxic TRAIL receptor|death receptor 4|tumor necrosis factor receptor superfamily member 10A|tumor necrosis factor receptor superfamily member 10a variant 2
Swissprots	O00220 Q96E62 A8K5I4 Q53Y72
Accessions	ABK41896 CCA94571 CCQ43238 EAW63636 O00220 AK291299 BAF83988 BC012866 AAH12866 BT006906 AAP35552 CN423254 DB101031 DQ891791 ABM82717 DQ894973 ABM85899 FJ795027 ACO37639 JF729355 AEB77762 U90875 AAC51226 NM_003844 NP_003835
Function	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. {ECO:0000269|PubMed:9430227}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Top Pathways	Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DR4 CRISPR/Cas9 KO Plasmid (h) - sc-400747 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DR4 HDR Plasmid (h) - sc-400747-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR4 Double Nickase Plasmid (h) - sc-400747-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR4 Double Nickase Plasmid (h2) - sc-400747-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR4 CRISPR Activation Plasmid (h) - sc-400747-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DR4 CRISPR Activation Plasmid (h2) - sc-400747-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DR4 Lentiviral Activation Particles (h) - sc-400747-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR4 Lentiviral Activation Particles (h2) - sc-400747-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR4 siRNA (h) - sc-35218 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DR4 shRNA Plasmid (h) - sc-35218-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DR4 shRNA (h) Lentiviral Particles - sc-35218-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU008861 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1137 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1137 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00843 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00843

TNFRSF10A siRNA (Human) - CRH5797 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TRAIL R1/TNFRSF10A RNAi - H00008797-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TNFRSF10A - MBS8225742 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TNFRSF10A (NM_003844.3) - SHH431848 from Creative biogene Category siRNA Species Reactivities Human

Human TNFRSF10A siRNA - orb266299 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TNFRSF10A shRNA Plasmid (Human) - CHH5797 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TNFRSF10A miRNA 3'UTR clone - MiUTR3H-06118 from Creative biogene Species Reactivities Human

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