TNFRSF10A

Gene Symbol TNFRSF10A
Entrez Gene 8797
Alt Symbol APO2, CD261, DR4, TRAILR-1, TRAILR1
Species Human
Gene Type protein-coding
Description tumor necrosis factor receptor superfamily, member 10a
Other Description TNF-related apoptosis-inducing ligand receptor 1|TRAIL receptor 1|TRAIL-R1|cytotoxic TRAIL receptor|death receptor 4|tumor necrosis factor receptor superfamily member 10A|tumor necrosis factor receptor superfamily member 10a variant 2
Swissprots O00220 Q96E62 A8K5I4 Q53Y72
Accessions ABK41896 CCA94571 CCQ43238 EAW63636 O00220 AK291299 BAF83988 BC012866 AAH12866 BT006906 AAP35552 CN423254 DB101031 DQ891791 ABM82717 DQ894973 ABM85899 FJ795027 ACO37639 JF729355 AEB77762 U90875 AAC51226 NM_003844 NP_003835
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. {ECO:0000269|PubMed:9430227}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Top Pathways Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, Measles, Influenza A

DR4 (B-9) - sc-8411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DR4 (B-9): sc-8411. Western blot analysis of human recombinant DR4 fusion protein.

DR4 (C-20) - sc-6823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DR4 (C-20): sc-6823. Western blot analysis of DR4 expression in non-transfected: sc-110760 (A) and human DR4 transfected: sc-112977 (B) 293 whole cell lysates.

DR4 (DR4.1) - sc-32255 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DR4 (DR4.1): sc-32255. Indirect FCM analysis of BJAB cells stained with DR4 (DR4.1), followed by PE-conjugated goat anti-mouse IgG<sub>1</sub>: sc-3764. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>, sc-3877.

DR4 (H-130) - sc-7863 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DR4 (H-130): sc-7863. Western blot analysis of DR4 expression in non-transfected: sc-110760 (A) and human DR4 transfected: sc-112977 (B) 293 whole cell lysates.

DR4 (L-20) - sc-31344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DR4 (L-20): sc-31344. Western blot analysis of DR4 expression in K-562 whole cell lysate.

DR4 (N-19) - sc-6824 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DR4 (N-19): sc-6824. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane staining.

DR4 (B-N28) - sc-65312 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
DR4 (B-N28): sc-65312. Western blot analysis of DR4 expression in non-transfected: sc-110760 (A) and human DR4 transfected: sc-112977 (B) 293 whole cell lysates.

Anti-DR4 [DR-4-02] antibody (Allophycocyanin) - ab192337 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DR-4-02

Anti-DR4 antibody - ab8414 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DR4 antibody (ab8414) at 1/500 dilution + HeLa total cell lysateObserved band size : 57 kDa (why is the actual band size different from the predicted?)

Anti-DR4 antibody - ab8415 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DR4 antibody (ab8415)Lane 1 : H: HeLaLane 2 : K: K562Lane 3 : J: Jurkat whole cell lysateObserved band size : 57 kDa (why is the actual band size different from the predicted?)

Anti-DR4 antibody - ab101012 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast tissue labelling DR4 with ab101012 at a dilution of 1/100.

Anti-DR4 antibody - ab69947 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DR4 antibody (ab69947) at 1/500 dilutionLane 1 : K562 cell extractLane 2 : COS7 cell extractLane 3 : RAW264.7 cell extractLane 4 : K562 cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-DR4 antibody [32A242] - ab13890 from Abcam

Prices $382.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 32A242
Overlay histogram showing Jurkat cells stained with ab13890 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab13890, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive result in 4% paraformaldehyde (10 min) fixed Jurkat cells used under the same conditions. Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-DR4 antibody [B-N28] - ab59481 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-N28

Anti-DR4 antibody [B-N36] - ab34228 from Abcam

Prices $372.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-N36

Anti-DR4 antibody [B-N36] (Phycoerythrin) - ab34933 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone B-N36

Anti-DR4 antibody [DR-4-02] (FITC) - ab59047 from Abcam

Prices $186.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone DR-4-02

Anti-DR4 antibody [DR-4-02] (Phycoerythrin) - ab65810 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone DR-4-02

Anti-DR4 antibody [DR-4-02] - Low endotoxin, Azide free - ab14738 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DR-4-02
Flow Cytometry analysis of DR4 expression on the surface of hematopoietic cell lines. Cells were stained with purified anti-DR4 antibodies (ab14738) followed by Goat anti-mouse IgG PE. Histograms: Red - Goat anti-mouse IgG PE (no primary antibody) Black - anti-DR4 comparative antibody Blue and Green - anti-DR4 (ab14738:DR-4-02) in duplicate staining

Anti-DR4 antibody [DR402] - ab176526 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DR402

Anti-DR4 antibody - N-terminal - ab190230 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling DR4 with ab190230 at 5 µg/ml, then with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-TNFRSF10A / DR4 Antibody IHC-plus™ - LS-B604 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TNFRSF10A / DR4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B604 concentration 5 ug/ml.

Anti-TNFRSF10A / DR4 Antibody - LS-C14902 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TNFRSF10A / DR4 Antibody - LS-C14907 from LifeSpan Bioscience

Prices $590.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFRSF10A / DR4 Antibody (Azide-free) - LS-C14903 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
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