| Gene Symbol |
EPHX1
|
| Entrez Gene |
2052
|
| Alt Symbol |
EPHX, EPOX, HYL1, MEH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
epoxide hydrolase 1, microsomal (xenobiotic)
|
| Other Description |
epoxide hydratase|epoxide hydrolase 1
|
| Swissprots |
Q9NPE7 Q9NQU6 P07099 Q5VTJ6 Q9NQV0 B2R8N0 Q9NQU7 Q9NP75 Q9NQU8 Q9NQV2 Q9NQU9 Q9NQV1
|
| Accessions |
AAB60649 AAC41694 AAF87726 AAF87727 AAF87728 AAF87729 AAF87730 AAF87731 AAF87732 AAF87733 AAF87734 AAF87735 AAF87736 AAF87737 AAF87738 AAX81410 EAW69754 EAW69755 EAW69756 EAW69757 P07099 AK313436 BAG36227 BC003567 AAH03567 BC008291 AAH08291 BC095430 AAH95430 BJ994650 BU541640 CR541963 CAG46761 DQ892506 ABM83432 DQ895720 ABM86646 HY180507 J03518 AAA61305 KF032815 AGL94507 L25878 AAA52389 L25879 AAA52390 M36374 AAA59580 U34722 X07936 CAA30759 Y00424 CAA68486 NM_000120 NP_000111 NM_001136018 NP_001129490 NM_001291163 NP_001278092
|
| Function |
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
|
| Subcellular Location |
Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Found in liver. {ECO:0000269|PubMed:12878321}.
|
| Top Pathways |
Bile secretion, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450
|
![Western Blot: EPHX1 Overexpression Lysate (Adult Normal) [NBL1-10294] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EPHX1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8071_EPHX1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10294-img0002.jpg)