POLR2E

Gene Symbol	POLR2E
Entrez Gene	5434
Alt Symbol	RPABC1, RPB5, XAP4, hRPB25, hsRPB5
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
Other Description	DNA directed RNA polymerase II 23 kda polypeptide|DNA-directed RNA polymerase II 23 kDa polypeptide|DNA-directed RNA polymerase II subunit E|DNA-directed RNA polymerase subunit RPABC1|DNA-directed RNA polymerases I, II, and III subunit RPABC1|RNA polymerases I, II, and III subunit ABC1|RPB5 homolog
Swissprots	P19388 O43380 D6W5Y1 Q9BT06 Q6PIH5 B2R6L4
Accessions	AAC03238 ADP92094 ADP92095 ADP92096 ADP92097 ADP92098 ADP92099 ADP92100 ADP92101 ADP92102 ADP92103 ADP92104 ADP92105 ADP92106 ADP92107 ADP92108 ADP92109 ADP92110 ADP92111 ADP92112 ADP92113 ADP92114 ADP92115 ADP92116 ADP92117 ADP92118 ADP92119 ADP92120 ADP92121 ADP92122 ADP92123 ADP92124 ADP92125 ADP92126 ADP92127 ADP92128 ADP92129 ADP92130 ADP92131 ADP92132 ADP92133 EAW69547 EAW69548 EAW69549 EAW69550 P19388 AK122813 AK295975 BAG58751 AK312625 BAG35511 BC004441 AAH04441 BC034144 AAH34144 D38251 BAA07406 DC414435 HQ448367 ADQ32847 J04965 AAA62401 S42643 AAB19339 XM_005259579 XP_005259636 XM_011528070 XP_011526372 NM_002695 NP_002686
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9852112}.
Top Pathways	Huntington's disease, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human POLR2E full length protein - ab81886 from Abcam Category Protein Source E. coli Species Human

POLR2E Antibody Blocking Peptide - LS-E3263 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

POLR2E Recombinant Protein - H00005434-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human POLR2E Protein - NBP2-23344 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

POLR2E-Antibody-N-term-Blocking-Peptide - BP14417a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human POLR2E protein - orb169050 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

POLR2E (1-210, His-tag) - AR50667PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

POLR2E (1-210, His-tag) - AR50667PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

POLR2E - H00005434-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

POLR2E - H00005434-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

POLR2E, 1-210aa, Human, His tag, E.coli - 01-P1843 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RNA Polymerase II fusion protein - Ag7386 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Human POLR2E Recombinant Protein - GWB-PPAT05 from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human POLR2E, His-tagged - POLR2E-28615TH from Creative Biomart Category Protein Source E. coli

Recombinant Human POLR2E, His-tagged - POLR2E-7061H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human POLR2E, GST-tagged - POLR2E-1843H from Creative Biomart Category Protein Source E.coli Species Human

POLR2E (L58) Peptide - BS3113P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant DNA-directed RNA polymerases I, II, and III subunit RPABC1(rpb-5) - CSB-YP427473CXX CSB-EP427473CXX CSB-BP427473CXX CSB-MP427473CXX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Caenorhabditis

Recombinant Human DNA-directed RNA polymerases I, II, and III subunit RPABC1(POLR2E) - CSB-YP018332HU CSB-EP018332HU CSB-BP018332HU CSB-MP018332HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

POLR2E, 1-210aa, Human, His tag, E.coli - ATGP1843 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

POLR2E Blocking Peptide - CBP4162 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Monkey

POLR2E Blocking Peptide - abx161373 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey

POLR2E - TP301266 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

POLR2E, Recombinant Protein - MBS205397 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 100 µg, 500 µg Source E Coli Species Human

Polymerase II Polypeptide E, Recombinant Protein - MBS146538 from MyBioSource Category Protein Prices $140.00, $205.00, $2,665.00 Sizes 5 µg, 20 µg, 1 mg Source E Coli

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