POLR2E

Gene Symbol	POLR2E
Entrez Gene	5434
Alt Symbol	RPABC1, RPB5, XAP4, hRPB25, hsRPB5
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
Other Description	DNA directed RNA polymerase II 23 kda polypeptide|DNA-directed RNA polymerase II 23 kDa polypeptide|DNA-directed RNA polymerase II subunit E|DNA-directed RNA polymerase subunit RPABC1|DNA-directed RNA polymerases I, II, and III subunit RPABC1|RNA polymerases I, II, and III subunit ABC1|RPB5 homolog
Swissprots	P19388 O43380 D6W5Y1 Q9BT06 Q6PIH5 B2R6L4
Accessions	AAC03238 ADP92094 ADP92095 ADP92096 ADP92097 ADP92098 ADP92099 ADP92100 ADP92101 ADP92102 ADP92103 ADP92104 ADP92105 ADP92106 ADP92107 ADP92108 ADP92109 ADP92110 ADP92111 ADP92112 ADP92113 ADP92114 ADP92115 ADP92116 ADP92117 ADP92118 ADP92119 ADP92120 ADP92121 ADP92122 ADP92123 ADP92124 ADP92125 ADP92126 ADP92127 ADP92128 ADP92129 ADP92130 ADP92131 ADP92132 ADP92133 EAW69547 EAW69548 EAW69549 EAW69550 P19388 AK122813 AK295975 BAG58751 AK312625 BAG35511 BC004441 AAH04441 BC034144 AAH34144 D38251 BAA07406 DC414435 HQ448367 ADQ32847 J04965 AAA62401 S42643 AAB19339 XM_005259579 XP_005259636 XM_011528070 XP_011526372 NM_002695 NP_002686
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9852112}.
Top Pathways	Huntington's disease, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

POLR2E (B-5) - sc-390979 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

POLR2E (C-10) - sc-390902 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

POLR2E (T-13) - sc-131331 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

POLR2E (H-204) - sc-366680 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-POLR2E antibody - ab169929 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POLR2E antibody - ab75066 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POLR2E antibody - ab68396 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POLR2E antibody - ab123284 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-POLR2E antibody - ab68085 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-POLR2E antibody [3B5] - ab119316 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B5

Anti-POLR2E antibody [3C5] - ab118000 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3C5

Anti-POLR2E antibody [EPR11750] - ab180151 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11750

Anti-POLR2E Antibody (clone 3B5) - LS-C337290 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B5

Anti-POLR2E Antibody (aa30-59, AP) - LS-C223702 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody (aa30-59, APC) - LS-C223703 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody (aa30-59, Biotin) - LS-C223704 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody (aa30-59, FITC) - LS-C223705 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody (aa30-59, Azide-free, HRP) - LS-C223706 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody (aa30-59, PE) - LS-C223707 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody (aa29-59) - LS-C324168 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody - LS-C341280 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody (aa30-59) - LS-C163850 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody (aa21-70) - LS-C119922 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POLR2E Antibody (clone 2A11) - LS-C172719 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2A11

Anti-POLR2E Antibody (Leu58) - LS-C177365 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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