| Gene Symbol |
SNRPE
|
| Entrez Gene |
6635
|
| Alt Symbol |
B-raf, HYPT11, SME, Sm-E
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small nuclear ribonucleoprotein polypeptide E
|
| Other Description |
sm protein E|small nuclear ribonucleoprotein E|snRNP-E
|
| Swissprots |
B2R5B9 Q5BKT2 P62304
|
| Accessions |
AAB59365 EAW91494 EAW91495 P62304 AI263891 AK307255 AK309140 AK312130 BAG35066 BC002639 AAH02639 BC072433 BC090951 AAH90951 D28435 BAA05801 DW441956 M15919 AAA36621 M37716 AAA90926 X12466 CAA31007 NM_001304464 NP_001291393 NM_003094 NP_003085 NR_130746
|
| Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23246290, ECO:0000269|PubMed:23333303}.
|
| Subcellular Location |
Cytoplasm, cytosol. Nucleus. Note=SMN- mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
|
| Tissue Specificity |
Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis. {ECO:0000269|PubMed:23246290}.
|
| Top Pathways |
Spliceosome
|
![Western Blot: SNRPE Overexpression Lysate (Adult Normal) [NBL1-16292] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SNRPE.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5095_SNRPE%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16292-img0002.jpg)