| Gene Symbol | DDX5 |
|---|---|
| Entrez Gene | 1655 |
| Alt Symbol | G17P1, HLR1, HUMP68, p68 |
| Species | Human |
| Gene Type | protein-coding |
| Description | DEAD (Asp-Glu-Ala-Asp) box helicase 5 |
| Other Description | ATP-dependent RNA helicase DDX5|DEAD (Asp-Glu-Ala-Asp) box polypeptide 5|DEAD box protein 5|DEAD box-5|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)|RNA helicase p68|probable ATP-dependent RNA helicase DDX5 |
| Swissprots | D3DU32 Q53Y61 O75681 B4DLW8 E7ETL9 B5BU21 P17844 |
| Accessions | AAB84094 CAA09408 EAW94202 EAW94203 P17844 AB209919 BAD93156 AB451257 BAG70071 AB451382 BAG70196 AK055995 AK297192 BAG59680 AK297753 BAG60103 AK297905 BAG60224 AK310318 AL133585 BC016027 AAH16027 BT006943 AAP35589 BX571764 CAE11890 DA191631 DQ890687 ABM81613 DQ893774 ABM84700 X15729 CAA33751 X52104 CAA36324 XM_005257111 XP_005257168 XM_006721738 XP_006721801 XM_011524456 XP_011522758 XM_011524457 XP_011522759 NM_004396 NP_004387 |
| Function | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcrip |
| Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:10837141, ECO:0000269|PubMed:1996094}. |
| Top Pathways | Spliceosome, Proteoglycans in cancer, Transcriptional misregulation in cancer |