DDX5

Gene Symbol	DDX5
Entrez Gene	1655
Alt Symbol	G17P1, HLR1, HUMP68, p68
Species	Human
Gene Type	protein-coding
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 5
Other Description	ATP-dependent RNA helicase DDX5|DEAD (Asp-Glu-Ala-Asp) box polypeptide 5|DEAD box protein 5|DEAD box-5|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)|RNA helicase p68|probable ATP-dependent RNA helicase DDX5
Swissprots	D3DU32 Q53Y61 O75681 B4DLW8 E7ETL9 B5BU21 P17844
Accessions	AAB84094 CAA09408 EAW94202 EAW94203 P17844 AB209919 BAD93156 AB451257 BAG70071 AB451382 BAG70196 AK055995 AK297192 BAG59680 AK297753 BAG60103 AK297905 BAG60224 AK310318 AL133585 BC016027 AAH16027 BT006943 AAP35589 BX571764 CAE11890 DA191631 DQ890687 ABM81613 DQ893774 ABM84700 X15729 CAA33751 X52104 CAA36324 XM_005257111 XP_005257168 XM_006721738 XP_006721801 XM_011524456 XP_011522758 XM_011524457 XP_011522759 NM_004396 NP_004387
Function	Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcrip
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:10837141, ECO:0000269|PubMed:1996094}.
Top Pathways	Spliceosome, Proteoglycans in cancer, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DDX5 peptide - ab22412 from Abcam Category Peptide

Human DDX5 peptide - ab23200 from Abcam Category Peptide Species Human

DDX5 Antibody Blocking Peptide - LS-E25695 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX5 Antibody Blocking Peptide - LS-E13018 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX5 Antibody Blocking Peptide - LS-E13017 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX5 Antibody Blocking Peptide - LS-E8980 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX5 Antibody Blocking Peptide - LS-E8981 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX5-Antibody-Center-Blocking-Peptide - BP7459c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DDX5-Antibody-C-term-Blocking-Peptide - BP7459b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DDX5 blocking peptide - GTX10261-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

DDX5 Blocking Peptide - 33R-7933 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DDX5 Blocking Peptide - 33R-8427 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DDX5 Peptide - AC21-0525-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DDX5 Peptide - 45-470P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

DDX5,p68 fusion protein - ag1237 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant DEAD Box Polypeptide 5 (DDX5) - RPL418Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

DDX5 Blocking Peptide - CBP3895 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

p68 RNA Helicase (N589) Peptide - BS1630P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant DEAD Box Polypeptide 5 (DDX5) - RPL418Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Probable ATP-dependent RNA helicase DDX5(DDX5) - CSB-YP006630HU CSB-EP006630HU CSB-BP006630HU CSB-MP006630HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DDX5 (pY593) Blocking Peptide - abx161834 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

DDX5 - TP300371 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Probable ATP-dependent RNA helicase DDX5 (DDX5), Recombinant Protein - MBS958623 from MyBioSource Category Protein Prices $1,040.00, $1,095.00, $1,215.00, $1,400.00, $1,465.00, $1,485.00, $1,545.00, $1,545.00, $1,675.00, $2,195.00, $2,205.00, $2,210.00, $2,535.00, $2,895.00 Sizes 50 µg (E-Coli), 50 µg (Yeast), 50 µg (Baculovirus), 200 µg (E-Coli), 50 µg (Mammalian-Cell), 200 µg (Yeast), 180 tests, 500 µg (E-Coli), 500 µg (Yeast), 1 mg (E-Coli), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

DDX5/p68 RNA helicase, Peptide - MBS425805 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

DDX5 fusion protein - Ag24808 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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