DDX5

Gene Symbol	DDX5
Entrez Gene	1655
Alt Symbol	G17P1, HLR1, HUMP68, p68
Species	Human
Gene Type	protein-coding
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 5
Other Description	ATP-dependent RNA helicase DDX5|DEAD (Asp-Glu-Ala-Asp) box polypeptide 5|DEAD box protein 5|DEAD box-5|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)|RNA helicase p68|probable ATP-dependent RNA helicase DDX5
Swissprots	D3DU32 Q53Y61 O75681 B4DLW8 E7ETL9 B5BU21 P17844
Accessions	AAB84094 CAA09408 EAW94202 EAW94203 P17844 AB209919 BAD93156 AB451257 BAG70071 AB451382 BAG70196 AK055995 AK297192 BAG59680 AK297753 BAG60103 AK297905 BAG60224 AK310318 AL133585 BC016027 AAH16027 BT006943 AAP35589 BX571764 CAE11890 DA191631 DQ890687 ABM81613 DQ893774 ABM84700 X15729 CAA33751 X52104 CAA36324 XM_005257111 XP_005257168 XM_006721738 XP_006721801 XM_011524456 XP_011522758 XM_011524457 XP_011522759 NM_004396 NP_004387
Function	Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcrip
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:10837141, ECO:0000269|PubMed:1996094}.
Top Pathways	Spliceosome, Proteoglycans in cancer, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® DDX5 siRNA I - 8626 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® DDX5 siRNA II - 8627 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

p68 RNA Helicase CRISPR/Cas9 KO Plasmid (h) - sc-402401 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p68 RNA Helicase HDR Plasmid (h) - sc-402401-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p68 RNA Helicase Double Nickase Plasmid (h) - sc-402401-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p68 RNA Helicase Double Nickase Plasmid (h2) - sc-402401-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p68 RNA Helicase CRISPR Activation Plasmid (h) - sc-402401-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p68 RNA Helicase CRISPR Activation Plasmid (h2) - sc-402401-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p68 RNA Helicase Lentiviral Activation Particles (h) - sc-402401-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p68 RNA Helicase Lentiviral Activation Particles (h2) - sc-402401-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p68 RNA Helicase siRNA (h) - sc-37141 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p68 RNA Helicase shRNA Plasmid (h) - sc-37141-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p68 RNA Helicase shRNA (h) Lentiviral Particles - sc-37141-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DDX5 RNAi - H00001655-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU129271 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN7063 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7063 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

DDX5 siRNA (Human) - CRH1167 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DDX5 - MBS8218680 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human DDX5 (NM_004396.3) - SHH276089 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DDX5(NM_004396.3) - SHG227323 from Creative biogene Category siRNA Species Reactivities Human

Human DDX5 siRNA - orb261669 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DDX5 shRNA Plasmid (Human) - CHH1167 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

DDX5 miRNA 3'UTR clone - MiUTR1H-02738 from Creative biogene Species Reactivities Human

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