GPHN

Gene Symbol GPHN
Entrez Gene 10243
Alt Symbol GEPH, GPH, GPHRYN, HKPX1, MOCODC
Species Human
Gene Type protein-coding
Description gephyrin
Other Description -
Swissprots Q9NQX3 Q9P2G2 Q9H4E9
Accessions EAW80923 EAW80924 EAW80925 EAW80926 Q9NQX3 AB037806 BAA92623 AF272663 AAF81785 AJ272033 CAC81240 AJ272343 CAC10537 AK025169 AK294532 BAH11801 AK295577 BAH12110 AK297447 BAH12583 AK315569 BAG37944 BC030016 AAH30016 BQ575870 DQ892463 ABM83389 DQ895675 ABM86601 XM_005267254 XP_005267311 XM_011536340 XP_011534642 XM_011536342 XP_011534644 XM_011536343 XP_011534645 XM_011536344 XP_011534646 XM_011536345 XP_011534647 XM_011536346 XP_011534648 XM_011536347 XP_011534649 XM_011536348 XP_011534650 XM_011536349 XP_011534651 NM_001024218 NP_001019389 NM_020806 NP_065857
Function Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000250}.
Subcellular Location Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Cytoplasmic face of glycinergic postsynaptic membranes. {ECO:0000250}.
Top Pathways GABAergic synapse

Gephyrin Antibody - 14304 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Gephyrin Antibody (upper) and α/β-Tubulin Antibody #2148 (lower). As expected, gephyrin protein expression is not detected in A172 cells.

Gephyrin (G-6) - sc-25311 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Gephyrin (G-6): sc-25311. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in glomeruli and tubuli at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Gephyrin (R-300) - sc-14003 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Gephyrin (R-300): sc-14003. Western blot analysis of Gephyrin expression in rat brain tissue extract.

Gephyrin (N-20) - sc-32561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Gephyrin (R-20) - sc-6411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Gephyrin (R-20): sc-6411. Immunofluorescence staining of methanol-fixed BC<sub>3</sub>H1 cells showing cytoplasmic localization.

Gephyrin (I-20) - sc-32562 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Gephyrin (B-4) - sc-55469 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Gephyrin (B-4): sc-55469. Western blot analysis of Gephyrin expression in H4 (A), 3611-RF (B) and PC-12 (C) whole cell lysates and rat brain tissue extract (D).

Gephyrin (45) - sc-135920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Gephyrin (45): sc-135920. Western blot analysis of Gephyrin expression in rat brain tissue extract.

Anti-Gephyrin antibody - ab136343 from Abcam

Prices $385.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
IHC-P image of Gephyrin staining on rat Caudate putamen sections using ab136343 (1:100). The sections were deparaffinized and subjected to heat mediated antigen retrieval uisng citric acid. The sections were then blocked using 1% BSA for 10 mins at 21°C. ab136343 was diluted 1:100 and incubated with the section for 16 hours at 21°C. The secondary antibody used was ab6876 - Goat polyclonal to Chicken IgY H&L conjugated to Biotin (1:200)

Anti-Gephyrin antibody [2C2] - ab124385 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C2
All lanes : Anti-Gephyrin antibody [2C2] (ab124385) at 1/500 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY Gephyrin cDNA Lysates/proteins at 5 µg per lane.

Anti-Gephyrin antibody [7C6] - ab117975 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7C6
All lanes : Anti-Gephyrin antibody [7C6] (ab117975) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY GephyrinLysates/proteins at 5 µg per lane.

Anti-Gephyrin antibody [EPR12650] - ab181382 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12650
All lanes : Anti-Gephyrin antibody [EPR12650] (ab181382) at 1/1000 dilutionLane 1 : Fetal brain tissue lysateLane 2 : 293T cell lysateLane 3 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.

Anti-Gephyrin antibody [EPR12651(B)] - ab177154 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12651(B)
All lanes : Anti-Gephyrin antibody [EPR12651(B)] (ab177154) at 1/1000 dilutionLane 1 : Human fetal brain lysateLane 2 : 293T lysateLane 3 : Jurkat lysateLane 4 : SH-SY5Y lysateLane 5 : C6 lysateLane 6 : Raw264.7 lysateLane 7 : PC12 lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-Gephyrin Antibody (aa180-229) - LS-C102405 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GPHN / Gephyrin antibody LS-C102405 Western blot of 721_B cell lysate.

Anti-Gephyrin Antibody (aa396-445) - LS-C102406 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GPHN / Gephyrin antibody LS-C102406 Western blot of Jurkat lysate.

Anti-Gephyrin Antibody (aa2-188) - LS-C182863 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-Gephyrin Antibody (aa437-466, APC) - LS-C222646 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Gephyrin Antibody (aa437-466, Biotin) - LS-C222647 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Gephyrin Antibody (aa437-466, FITC) - LS-C222648 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Gephyrin Antibody (aa437-466, Azide-free, HRP) - LS-C222649 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Gephyrin Antibody (aa437-466, PE) - LS-C222651 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Gephyrin Antibody (aa437-466, AP) - LS-C226777 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Gephyrin Antibody (aa444-474) - LS-C321723 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Gephyrin Antibody (clone 7B6) - LS-C172569 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7B6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPHN (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GPHN.

Anti-Gephyrin Antibody (aa437-466) - LS-C166609 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GPHN Antibody IHC of formalin-fixed and paraffin-embedded brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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