| Gene Symbol |
GPHN
|
| Entrez Gene |
10243
|
| Alt Symbol |
GEPH, GPH, GPHRYN, HKPX1, MOCODC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gephyrin
|
| Other Description |
-
|
| Swissprots |
Q9NQX3 Q9P2G2 Q9H4E9
|
| Accessions |
EAW80923 EAW80924 EAW80925 EAW80926 Q9NQX3 AB037806 BAA92623 AF272663 AAF81785 AJ272033 CAC81240 AJ272343 CAC10537 AK025169 AK294532 BAH11801 AK295577 BAH12110 AK297447 BAH12583 AK315569 BAG37944 BC030016 AAH30016 BQ575870 DQ892463 ABM83389 DQ895675 ABM86601 XM_005267254 XP_005267311 XM_011536340 XP_011534642 XM_011536342 XP_011534644 XM_011536343 XP_011534645 XM_011536344 XP_011534646 XM_011536345 XP_011534647 XM_011536346 XP_011534648 XM_011536347 XP_011534649 XM_011536348 XP_011534650 XM_011536349 XP_011534651 NM_001024218 NP_001019389 NM_020806 NP_065857
|
| Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000250}.
|
| Subcellular Location |
Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Cytoplasmic face of glycinergic postsynaptic membranes. {ECO:0000250}.
|
| Top Pathways |
GABAergic synapse
|