| Gene Symbol |
SMPD1
|
| Entrez Gene |
6609
|
| Alt Symbol |
ASM, ASMASE, NPD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sphingomyelin phosphodiesterase 1, acid lysosomal
|
| Other Description |
acid sphingomyelinase|sphingomyelin phosphodiesterase
|
| Swissprots |
Q16837 A8K8M3 Q16841 P17406 E9PKS3 P17405 Q13811
|
| Accessions |
AAA58378 AAA75008 AAA75009 AAL79527 CAA45145 CDM61370 EAW68726 EAW68727 EAW68728 EAW68729 P17405 AA746054 AB209775 BAD93012 AK292388 BAF85077 AY649987 AAV68198 BC041164 AAH41164 BI599208 BM686561 BU845962 HQ132745 ADW08999 HQ132746 ADW09000 HQ132747 ADW09001 HQ132748 ADW09002 M59916 AAA58377 X52678 CAA36901 X52679 CAA36902 X59960 CAA42584 XM_005253075 XP_005253132 XM_011520303 XP_011518605 XM_011520304 XP_011518606 XR_930886 NM_000543 NP_000534 NM_001007593 NP_001007594 NR_027400
|
| Function |
Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.
|
| Subcellular Location |
Lysosome.
|
| Top Pathways |
Lysosome, Sphingolipid signaling pathway, Sphingolipid metabolism
|
