| Gene Symbol |
LRRFIP2
|
| Entrez Gene |
9209
|
| Alt Symbol |
HUFI-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat (in FLII) interacting protein 2
|
| Other Description |
LRR FLII-interacting protein 2|leucine-rich repeat flightless-interacting protein 2
|
| Swissprots |
Q9NXH5 B4DY63 A8MXR0 A8K649 Q68CV3 Q9Y608
|
| Accessions |
EAW64486 EAW64487 EAW64488 EAW64489 EAW64490 EAW64491 Q9Y608 AF115509 AAD41257 AK000255 BAA91035 AK024692 AK026336 AK124432 AK291514 BAF84203 AK302282 BAG63625 BC053668 AAH53668 BX648794 CR749705 CAH18481 DB033703 DC336346 R27776 XM_005265538 XP_005265595 XM_005265539 XP_005265596 XM_005265540 XP_005265597 XM_005265550 XP_005265607 XM_005265551 XP_005265608 XM_005265553 XP_005265610 XM_005265554 XP_005265611 XM_005265555 XP_005265612 XM_005265556 XP_005265613 XM_005265557 XP_005265614 XM_006713385 XP_006713448 XM_006713386 XP_006713449 XM_006713387 XP_006713450 XM_006713388 XP_006713451 XM_006713389 XP_006713452 XM_006713390 XP_006713453 XM_006713392 XP_006713455 XM_006713393 XP_006713456 XM_006713394 XP_006713457 XM_006713395 XP_006713458 XM_006713396 XP_006713459 XM_006713397 XP_006713460 XM_006713399 XP_006713462 XM_006713400 XP_006713463 XM_006713402 XP_006713465 XM_006713403 XP_006713466 XM_006713404 XP_006713467 XM_011534217 XP_011532519 XM_011534218 XP_011532520 XM_011534219 XP_011532521 XM_011534220 XP_011532522 XM_011534221 XP_011532523 XM_011534222 XP_011532524 XM_011534223 XP_011532525 XM_011534224 XP_011532526 XM_011534225 XP_011532527 XM_011534226 XP_011532528 XM_011534227 XP_011532529 XM_011534228 XP_011532530 XM_011534229 XP_011532531 NM_001134369 NP_001127841 NM_001282691 NP_001269620 NM_006309 NP_006300 NM_017724 NP_060194
|
| Function |
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}.
|
| Tissue Specificity |
Widely expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:10366446}.
|