| Gene Symbol | LRRFIP2 |
|---|---|
| Entrez Gene | 9209 |
| Alt Symbol | HUFI-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | leucine rich repeat (in FLII) interacting protein 2 |
| Other Description | LRR FLII-interacting protein 2|leucine-rich repeat flightless-interacting protein 2 |
| Swissprots | Q9NXH5 B4DY63 A8MXR0 A8K649 Q68CV3 Q9Y608 |
| Accessions | EAW64486 EAW64487 EAW64488 EAW64489 EAW64490 EAW64491 Q9Y608 AF115509 AAD41257 AK000255 BAA91035 AK024692 AK026336 AK124432 AK291514 BAF84203 AK302282 BAG63625 BC053668 AAH53668 BX648794 CR749705 CAH18481 DB033703 DC336346 R27776 XM_005265538 XP_005265595 XM_005265539 XP_005265596 XM_005265540 XP_005265597 XM_005265550 XP_005265607 XM_005265551 XP_005265608 XM_005265553 XP_005265610 XM_005265554 XP_005265611 XM_005265555 XP_005265612 XM_005265556 XP_005265613 XM_005265557 XP_005265614 XM_006713385 XP_006713448 XM_006713386 XP_006713449 XM_006713387 XP_006713450 XM_006713388 XP_006713451 XM_006713389 XP_006713452 XM_006713390 XP_006713453 XM_006713392 XP_006713455 XM_006713393 XP_006713456 XM_006713394 XP_006713457 XM_006713395 XP_006713458 XM_006713396 XP_006713459 XM_006713397 XP_006713460 XM_006713399 XP_006713462 XM_006713400 XP_006713463 XM_006713402 XP_006713465 XM_006713403 XP_006713466 XM_006713404 XP_006713467 XM_011534217 XP_011532519 XM_011534218 XP_011532520 XM_011534219 XP_011532521 XM_011534220 XP_011532522 XM_011534221 XP_011532523 XM_011534222 XP_011532524 XM_011534223 XP_011532525 XM_011534224 XP_011532526 XM_011534225 XP_011532527 XM_011534226 XP_011532528 XM_011534227 XP_011532529 XM_011534228 XP_011532530 XM_011534229 XP_011532531 NM_001134369 NP_001127841 NM_001282691 NP_001269620 NM_006309 NP_006300 NM_017724 NP_060194 |
| Function | May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}. |
| Tissue Specificity | Widely expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:10366446}. |
LRRFIP2 CRISPR/Cas9 KO Plasmid (h) - sc-403163 from Santa Cruz Biotechnology
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LRRFIP2 HDR Plasmid (h) - sc-403163-HDR from Santa Cruz Biotechnology
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LRRFIP2 Double Nickase Plasmid (h) - sc-403163-NIC from Santa Cruz Biotechnology
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LRRFIP2 Double Nickase Plasmid (h2) - sc-403163-NIC-2 from Santa Cruz Biotechnology
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LRRFIP2 CRISPR Activation Plasmid (h) - sc-403163-ACT from Santa Cruz Biotechnology
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LRRFIP2 CRISPR Activation Plasmid (h2) - sc-403163-ACT-2 from Santa Cruz Biotechnology
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LRRFIP2 Lentiviral Activation Particles (h) - sc-403163-LAC from Santa Cruz Biotechnology
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LRRFIP2 Lentiviral Activation Particles (h2) - sc-403163-LAC-2 from Santa Cruz Biotechnology
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LRRFIP2 siRNA (h) - sc-77893 from Santa Cruz Biotechnology
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LRRFIP2 shRNA Plasmid (h) - sc-77893-SH from Santa Cruz Biotechnology
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LRRFIP2 shRNA (h) Lentiviral Particles - sc-77893-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU071721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12771 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07306 from Sigma-Aldrich
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LRRFIP2 siRNA (Human) - CRH6094 from Cohesion Biosciences
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shRNA set against Human Lrrfip2 (NM_006309.2) - SHH334947 from Creative biogene
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LRRFIP2 shRNA Plasmid (Human) - CHH6094 from Cohesion Biosciences
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LRRFIP2 miRNA 3'UTR clone - MiUTR3H-13111 from Creative biogene
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LRRFIP2 miRNA 3'UTR clone - MiUTR3H-13112 from Creative biogene
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LRRFIP2 miRNA 3'UTR clone - MiUTR3H-13113 from Creative biogene
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