Gene Symbol | CRIM1 |
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Entrez Gene | 51232 |
Alt Symbol | CRIM-1, S52 |
Species | Human |
Gene Type | protein-coding |
Description | cysteine rich transmembrane BMP regulator 1 (chordin-like) |
Other Description | cysteine-rich motor neuron 1 protein|cysteine-rich repeat-containing protein S52 |
Swissprots | Q2M2G4 Q7LCQ5 Q9H318 Q9NZV1 Q59GH0 |
Accessions | AAG37011 AAX88862 AAY14649 AAY14679 EAX00426 Q9NZV1 AB209139 BAD92376 AF167706 AAF34409 AK026159 AK300817 BAG62472 AY358371 AAQ88737 BC026227 BC111989 AAI11990 BC113371 AAI13372 BX648755 CR627451 XM_005264357 XP_005264414 XM_011532898 XP_011531200 XM_011532899 XP_011531201 XM_011532900 XP_011531202 XM_011532901 XP_011531203 XR_939687 NM_016441 NP_057525 |
Function | May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. {ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}. |
Subcellular Location | Processed cysteine-rich motor neuron 1 protein: Secreted. |
Tissue Specificity | Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). {ECO:0000269|PubMed:10642437, ECO:0000269|PubMed:12464430}. |
CRIM1 CRISPR/Cas9 KO Plasmid (h) - sc-404886 from Santa Cruz Biotechnology
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CRIM1 HDR Plasmid (h) - sc-404886-HDR from Santa Cruz Biotechnology
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CRIM1 Double Nickase Plasmid (h) - sc-404886-NIC from Santa Cruz Biotechnology
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CRIM1 Double Nickase Plasmid (h2) - sc-404886-NIC-2 from Santa Cruz Biotechnology
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CRIM1 CRISPR Activation Plasmid (h) - sc-404886-ACT from Santa Cruz Biotechnology
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CRIM1 CRISPR Activation Plasmid (h2) - sc-404886-ACT-2 from Santa Cruz Biotechnology
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CRIM1 Lentiviral Activation Particles (h) - sc-404886-LAC from Santa Cruz Biotechnology
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CRIM1 Lentiviral Activation Particles (h2) - sc-404886-LAC-2 from Santa Cruz Biotechnology
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CRIM1 siRNA (h) - sc-94828 from Santa Cruz Biotechnology
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CRIM1 shRNA Plasmid (h) - sc-94828-SH from Santa Cruz Biotechnology
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CRIM1 shRNA (h) Lentiviral Particles - sc-94828-V from Santa Cruz Biotechnology
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CRIM1 RNAi - H00051232-R04 from Novus Biologicals
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MISSION® esiRNA - EHU003871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6570 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6570 from Sigma-Aldrich
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CRIM1 siRNA (Human) - CRH9622 from Cohesion Biosciences
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CRIM1 - MBS8234442 from MyBioSource
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shRNA set against Human CRIM1 (NM_016441.2) - SHH269513 from Creative biogene
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Human CRIM1 siRNA - orb270124 from Biorbyt
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CRIM1 shRNA Plasmid (Human) - CHH9622 from Cohesion Biosciences
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CRIM1 miRNA 3'UTR clone - MiUTR4H-TG10975 from Creative biogene
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