A2ML1

Gene Symbol	A2ML1
Entrez Gene	144568
Alt Symbol	CPAMD9
Species	Human
Gene Type	protein-coding
Description	alpha-2-macroglobulin-like 1
Other Description	C3 and PZP-like, alpha-2-macroglobulin domain containing 9|alpha-2-macroglobulin-like protein 1
Swissprots	B7Z7V4 Q96LQ8 Q6ZW52 F5H2Z2 Q8N1M4 A8K2U0 Q2M224 Q6ZW53 D3DUV3 B5MDD1
Accessions	A8K2U0 EAW88602 EAW88603 EAW88604 EAW88605 EAW88606 EAW88607 AK057908 BAB71612 AK096448 BAC04793 AK122624 BAC85494 AK123591 BAC85653 AK123592 BAC85654 AK123601 BAG53918 AK290355 BAF83044 AK302555 BAH13740 AL832139 AL832750 AL833479 BC093840 AAH93840 BC112131 AAI12132 BC172370 AAI72370 BF330285 BF354222 BX647674 BX648231 DA436610 DA456454 DA461408 EL594621 XM_011520566 XP_011518868 XM_011520567 XP_011518869 XR_931275 NM_001282424 NP_001269353 NM_144670 NP_653271
Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. {ECO:0000250|UniProtKB:P01023, ECO:0000269|PubMed:16298998}.
Subcellular Location	Secreted {ECO:0000269|PubMed:16298998}.
Tissue Specificity	In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon. {ECO:0000269|PubMed:16298998}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

α2ML1 (G-8) - sc-393082 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

α2ML1 (E-16) - sc-138824 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

α2ML1 (N-14) - sc-138825 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-A2ML1 antibody - ab72872 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-A2ML1 Antibody (aa345-373, AP) - LS-C250504 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody (aa345-373, Biotin) - LS-C250506 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody (aa345-373, FITC) - LS-C250507 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody (aa345-373, Azide-free, HRP) - LS-C250508 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody (aa345-373, PE) - LS-C250509 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody (aa345-373, APC) - LS-C250505 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody (aa1119-1348, Biotin) - LS-C297467 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody (aa1119-1348, FITC) - LS-C301858 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody - LS-C306012 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-A2ML1 Antibody (aa352-381) - LS-C319228 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody (aa345-373) - LS-C155823 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-A2ML1 Antibody (aa1119-1348) - LS-C292752 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

alpha 2-Macroglobulin-like 1/A2ML1 Antibody - NBP1-84392 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

alpha 2-Macroglobulin-like 1/A2ML1 Antibody - NBP2-32647 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

alpha 2-Macroglobulin-like 1/A2ML1 Antibody - H00144568-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

alpha 2-Macroglobulin-like 1/A2ML1 Antibody - H00144568-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-A2ML1 antibody produced in rabbit - HPA038848 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-A2ML1 antibody produced in mouse - SAB1408359 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

ANTI-A2ML1(N-TERMINAL) antibody produced in rabbit - SAB1306960 from Sigma-Aldrich Prices $326.00 Sizes 40 tst Host Rabbit Clonality Polyclonal

Anti-A2ML1 antibody produced in rabbit - HPA038847 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

A2ML1 Antibody - N-terminal region (OAAB02144) - OAAB02144 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

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