A2ML1

Gene Symbol	A2ML1
Entrez Gene	144568
Alt Symbol	CPAMD9
Species	Human
Gene Type	protein-coding
Description	alpha-2-macroglobulin-like 1
Other Description	C3 and PZP-like, alpha-2-macroglobulin domain containing 9|alpha-2-macroglobulin-like protein 1
Swissprots	B7Z7V4 Q96LQ8 Q6ZW52 F5H2Z2 Q8N1M4 A8K2U0 Q2M224 Q6ZW53 D3DUV3 B5MDD1
Accessions	A8K2U0 EAW88602 EAW88603 EAW88604 EAW88605 EAW88606 EAW88607 AK057908 BAB71612 AK096448 BAC04793 AK122624 BAC85494 AK123591 BAC85653 AK123592 BAC85654 AK123601 BAG53918 AK290355 BAF83044 AK302555 BAH13740 AL832139 AL832750 AL833479 BC093840 AAH93840 BC112131 AAI12132 BC172370 AAI72370 BF330285 BF354222 BX647674 BX648231 DA436610 DA456454 DA461408 EL594621 XM_011520566 XP_011518868 XM_011520567 XP_011518869 XR_931275 NM_001282424 NP_001269353 NM_144670 NP_653271
Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. {ECO:0000250|UniProtKB:P01023, ECO:0000269|PubMed:16298998}.
Subcellular Location	Secreted {ECO:0000269|PubMed:16298998}.
Tissue Specificity	In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon. {ECO:0000269|PubMed:16298998}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human A2ML1 full length protein - ab165513 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

A2ML1 Antibody Blocking Peptide - LS-E7564 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human alpha 2-Macroglobulin-like 1/A2ML1 Protein - H00144568-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

A2ML1-Antibody-N-term-Blocking-Peptide - BP4723a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human alpha 2-Macroglobulin-like 1, CF - 7836-AM-050 from R&D Systems Category Protein Source Human embryonic kidney cell, HEK293-derived, Glu18-Glu1454, with a C-terminal 6-His tag

Human a2ML1 Protein - abx065259 from Abbexa Category Protein Source E.coli Species Human

A2ML1 / CPAMD9 - H00144568-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

A2ML1 / CPAMD9 - H00144568-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

A2ML1 fusion protein - ag18656 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

A2ML1 fusion protein - ag18459 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human A2ML1, His-tagged - A2ML1-3327H from Creative Biomart Category Protein Source E. Coli or Yeast Species Human

Recombinant Human a2ML1 - a2ML1-3328H from Creative Biomart Category Protein Source E. Coli Species Human

Recombinant Human A2ML1 Protein, His-tagged - A2ML1-827H from Creative Biomart Category Protein Source HEK293 Cells Species Human

Recombinant Alpha-2-Macroglobulin Like Protein 1 (a2ML1) - RPA965Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Alpha-2-Macroglobulin Like Protein 1 (a2ML1) - RPA965Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial - CSB-YP001005HU CSB-EP001005HU CSB-BP001005HU CSB-MP001005HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human alpha 2-Macroglobulin-like 1 Protein, CF - 7836-AM from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Human embryonic kidney cell, HEK293-derived Glu18-Glu1454, with a C-terminal 6-His tag Species Human

Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial - MBS1205201 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Alpha-2-macroglobulin-like 1 (A2ML1) - TP319615 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

alpha 2-Macroglobulin-like 1/A2ML1 Recombinant Protein Antigen - NBP1-84392PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

alpha 2-Macroglobulin-like 1/A2ML1 Recombinant Protein Antigen - NBP2-32647PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

A2ML1 Peptide, Human - M34GP00003H from Creative Peptides Category Peptide Source Synthetic. Species Human

A2ML1 fusion protein - Ag25818 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

A2ML1 Recombinant Protein (OPCD00985) - OPCD00985 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant Human alpha 2-Macroglobulin-like 1 Protein, CF - 7836-AM from Novus Biologicals Category Protein Prices $329.00 Sizes 50 µg Species Human

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