| Gene Symbol |
LATS2
|
| Entrez Gene |
26524
|
| Alt Symbol |
KPM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
large tumor suppressor kinase 2
|
| Other Description |
LATS (large tumor suppressor, Drosophila) homolog 2|LATS, large tumor suppressor, homolog 2|kinase phosphorylated during mitosis protein|large tumor suppressor homolog 2|serine/threonine kinase KPM|serine/threonine-protein kinase LATS2|serine/threonine-protein kinase kpm|warts-like kinase
|
| Swissprots |
Q9P2X1 B1AM47 Q9NRM7
|
| Accessions |
EAX08286 EAX08287 Q9NRM7 AB028019 BAA92381 AB209897 BAD93134 AF207547 AAF80561 AK123520 AK314235 BAG36905 BC036437 BC071572 BC127671 BC156423 AAI56424 BC172545 AAI72545 BQ774580 DB452765 XM_005266342 XP_005266399 XM_011535042 XP_011533344 NM_014572 NP_055387
|
| Function |
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilizatio
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.
|
| Tissue Specificity |
Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined. {ECO:0000269|PubMed:10673337, ECO:0000269|PubMed:10871863}.
|
| Top Pathways |
Hippo signaling pathway
|