LATS2

Gene Symbol	LATS2
Entrez Gene	26524
Alt Symbol	KPM
Species	Human
Gene Type	protein-coding
Description	large tumor suppressor kinase 2
Other Description	LATS (large tumor suppressor, Drosophila) homolog 2|LATS, large tumor suppressor, homolog 2|kinase phosphorylated during mitosis protein|large tumor suppressor homolog 2|serine/threonine kinase KPM|serine/threonine-protein kinase LATS2|serine/threonine-protein kinase kpm|warts-like kinase
Swissprots	Q9P2X1 B1AM47 Q9NRM7
Accessions	EAX08286 EAX08287 Q9NRM7 AB028019 BAA92381 AB209897 BAD93134 AF207547 AAF80561 AK123520 AK314235 BAG36905 BC036437 BC071572 BC127671 BC156423 AAI56424 BC172545 AAI72545 BQ774580 DB452765 XM_005266342 XP_005266399 XM_011535042 XP_011533344 NM_014572 NP_055387
Function	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilizatio
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.
Tissue Specificity	Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined. {ECO:0000269|PubMed:10673337, ECO:0000269|PubMed:10871863}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

kpm CRISPR/Cas9 KO Plasmid (h) - sc-404134 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

kpm HDR Plasmid (h) - sc-404134-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kpm Double Nickase Plasmid (h) - sc-404134-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kpm Double Nickase Plasmid (h2) - sc-404134-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kpm CRISPR Activation Plasmid (h) - sc-404134-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

kpm CRISPR Activation Plasmid (h2) - sc-404134-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

kpm Lentiviral Activation Particles (h) - sc-404134-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kpm Lentiviral Activation Particles (h2) - sc-404134-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kpm siRNA (h) - sc-37444 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

kpm shRNA Plasmid (h) - sc-37444-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

kpm shRNA (h) Lentiviral Particles - sc-37444-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LATS2 RNAi - H00026524-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU055781 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1044 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1043 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1042 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN11569 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11569 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00046 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00046

LATS2 siRNA (Human) - CRH8848 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Lats2 (NM_014572.2) - SHH328691 from Creative biogene Category siRNA Species Reactivities Human

Human LATS2 siRNA - orb269350 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

LATS2 shRNA Plasmid (Human) - CHH8848 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

LATS2 miRNA 3'UTR clone - MiUTR1H-05588 from Creative biogene Species Reactivities Human

Search more