| Gene Symbol | PAK4 |
|---|---|
| Entrez Gene | 10298 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | p21 protein (Cdc42/Rac)-activated kinase 4 |
| Other Description | PAK-4|p21(CDKN1A)-activated kinase 4|p21-activated kinase 4|protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs|serine/threonine-protein kinase PAK 4 |
| Swissprots | Q8N4E1 O96013 Q9BU33 Q9ULS8 Q8NCH5 B4DGG6 Q8NDE3 |
| Accessions | EAW56858 EAW56859 EAW56860 EAW56861 EAW56862 EAW56863 EAW56864 EAW56865 EAW56866 O96013 AB032968 BAA86456 AF005046 AAD01210 AJ011855 CAA09820 AK074728 BAC11166 AK291839 BAF84528 AK293517 BAG56999 AK294586 BAG57777 AK300632 BAG62322 AK304651 BAG65427 AL834236 CAD38914 AM392622 CAL37500 AM392751 CAL37629 AM393512 CAL38389 AX775863 CAE11631 AX775865 CAE11632 AX775867 CAE11633 AX775869 CAE11634 AX775871 CAE11635 BC002921 AAH02921 BC011368 AAH11368 BC025282 AAH25282 BC034511 AAH34511 BG773480 BM129363 DQ891039 ABM81965 DQ894218 ABM85144 GQ129406 ACT64540 GQ129407 ACT64541 XM_011526316 XP_011524618 XM_011526317 XP_011524619 XM_011526318 XP_011524620 XM_011526319 XP_011524621 XM_011526320 XP_011524622 NM_001014831 NP_001014831 NM_001014832 NP_001014832 NM_001014834 NP_001014834 NM_001014835 NP_001014835 NM_005884 NP_005875 NM_001014833 |
| Function | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12356872}. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. |
| Tissue Specificity | Highest expression in prostate, testis and colon. |
| Top Pathways | Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway |