PAK4

Gene Symbol	PAK4
Entrez Gene	10298
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 4
Other Description	PAK-4|p21(CDKN1A)-activated kinase 4|p21-activated kinase 4|protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs|serine/threonine-protein kinase PAK 4
Swissprots	Q8N4E1 O96013 Q9BU33 Q9ULS8 Q8NCH5 B4DGG6 Q8NDE3
Accessions	EAW56858 EAW56859 EAW56860 EAW56861 EAW56862 EAW56863 EAW56864 EAW56865 EAW56866 O96013 AB032968 BAA86456 AF005046 AAD01210 AJ011855 CAA09820 AK074728 BAC11166 AK291839 BAF84528 AK293517 BAG56999 AK294586 BAG57777 AK300632 BAG62322 AK304651 BAG65427 AL834236 CAD38914 AM392622 CAL37500 AM392751 CAL37629 AM393512 CAL38389 AX775863 CAE11631 AX775865 CAE11632 AX775867 CAE11633 AX775869 CAE11634 AX775871 CAE11635 BC002921 AAH02921 BC011368 AAH11368 BC025282 AAH25282 BC034511 AAH34511 BG773480 BM129363 DQ891039 ABM81965 DQ894218 ABM85144 GQ129406 ACT64540 GQ129407 ACT64541 XM_011526316 XP_011524618 XM_011526317 XP_011524619 XM_011526318 XP_011524620 XM_011526319 XP_011524621 XM_011526320 XP_011524622 NM_001014831 NP_001014831 NM_001014832 NP_001014832 NM_001014834 NP_001014834 NM_001014835 NP_001014835 NM_005884 NP_005875 NM_001014833
Function	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12356872}. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways.
Tissue Specificity	Highest expression in prostate, testis and colon.
Top Pathways	Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PAK4 CRISPR/Cas9 KO Plasmid (h) - sc-401895 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PAK4 HDR Plasmid (h) - sc-401895-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PAK4 Double Nickase Plasmid (h) - sc-401895-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PAK4 Double Nickase Plasmid (h2) - sc-401895-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PAK4 CRISPR Activation Plasmid (h) - sc-401895-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PAK4 CRISPR Activation Plasmid (h2) - sc-401895-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PAK4 Lentiviral Activation Particles (h) - sc-401895-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PAK4 Lentiviral Activation Particles (h2) - sc-401895-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PAK4 siRNA (h) - sc-39060 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PAK4 shRNA Plasmid (h) - sc-39060-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PAK4 shRNA (h) Lentiviral Particles - sc-39060-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PAK4 RNAi - H00010298-R09 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PAK4 RNAi - H00010298-R10 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PAK4 RNAi - H00010298-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PAK4 RNAi - H00010298-R12 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PAK4 RNAi - H00010298-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU073951 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1493 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1495 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1496 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1494 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1497 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN16288 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16288 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13039 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr13039

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