| Gene Symbol |
HACD3
|
| Entrez Gene |
51495
|
| Alt Symbol |
B-IND1, BIND1, HSPC121, PTPLAD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
3-hydroxyacyl-CoA dehydratase 3
|
| Other Description |
butyrate-induced protein 1|butyrate-induced transcript 1|protein tyrosine phosphatase-like A domain containing 1|protein tyrosine phosphatase-like protein PTPLAD1|protein-tyrosine phosphatase-like A domain-containing protein 1|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
|
| Swissprots |
Q9NQA7 Q8NCB1 Q8NC86 A0PJA1 Q9P035 Q280Z3 B4DRF4 Q6PD63 Q8IUI5 Q96T12
|
| Accessions |
ABB83547 EAW77735 EAW77736 Q9P035 AF161470 AAF29085 AJ271091 CAB69070 AK027421 BAB55101 AK074857 BAC11249 AK074898 BAC11277 AK225120 AK299234 BAG61266 AL137412 BC000194 BC009056 BC011443 BC019873 AAH19873 BC035508 AAH35508 BC047685 AAH47685 BC058912 AAH58912 H21635 XM_011521664 XP_011519966 NM_016395 NP_057479
|
| Function |
Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
|
| Tissue Specificity |
Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes. {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506}.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism
|
