HACD3

Gene Symbol	HACD3
Entrez Gene	51495
Alt Symbol	B-IND1, BIND1, HSPC121, PTPLAD1
Species	Human
Gene Type	protein-coding
Description	3-hydroxyacyl-CoA dehydratase 3
Other Description	butyrate-induced protein 1|butyrate-induced transcript 1|protein tyrosine phosphatase-like A domain containing 1|protein tyrosine phosphatase-like protein PTPLAD1|protein-tyrosine phosphatase-like A domain-containing protein 1|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
Swissprots	Q9NQA7 Q8NCB1 Q8NC86 A0PJA1 Q9P035 Q280Z3 B4DRF4 Q6PD63 Q8IUI5 Q96T12
Accessions	ABB83547 EAW77735 EAW77736 Q9P035 AF161470 AAF29085 AJ271091 CAB69070 AK027421 BAB55101 AK074857 BAC11249 AK074898 BAC11277 AK225120 AK299234 BAG61266 AL137412 BC000194 BC009056 BC011443 BC019873 AAH19873 BC035508 AAH35508 BC047685 AAH47685 BC058912 AAH58912 H21635 XM_011521664 XP_011519966 NM_016395 NP_057479
Function	Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
Tissue Specificity	Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes. {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506}.
Top Pathways	Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PTPLAD1 full length protein - ab162573 from Abcam Category Protein Source Wheat germ Species Human

Human PTPLAD1 protein fragment - ab162574 from Abcam Category Protein Source Wheat germ Species Human

HACD3 / PTPLAD1 Antibody Blocking Peptide - LS-E6220 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HACD3 / PTPLAD1 Antibody Blocking Peptide - LS-E17134 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPLAD1 Partial Recombinant Protein - H00051495-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PTPLAD1 Protein - H00051495-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PTPLAD1-Antibody-N-term-Blocking-Peptide - BP18866a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTPLAD1 Blocking Peptide - 33R-9968 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTPLAD1 / BIND1 - H00051495-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PTPLAD1 / BIND1 - H00051495-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PTPLAD1 / BIND1 - H00051495-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PTPLAD1 Recombinant Protein Antigen - NBP1-88597PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PTPLAD1 Peptide, Human - M34GP12690H from Creative Peptides Category Peptide Source Synthetic. Species Human

3-hydroxyacyl-CoA dehydratase 3 (PTPLAD1), Recombinant Protein - MBS7028263 from MyBioSource Category Protein Prices $1,170.00, $2,155.00, $3,365.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

3-hydroxyacyl-CoA dehydratase 3 (PTPLAD1), Recombinant Protein - MBS7028265 from MyBioSource Category Protein Prices $1,170.00, $2,155.00, $3,365.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Orangutan

Recombinant Human HACD3 Protein, GST-tagged - HACD3-5270H from Creative Biomart Category Protein Source Wheat Germ Species Human

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