HACD3

Gene Symbol	HACD3
Entrez Gene	51495
Alt Symbol	B-IND1, BIND1, HSPC121, PTPLAD1
Species	Human
Gene Type	protein-coding
Description	3-hydroxyacyl-CoA dehydratase 3
Other Description	butyrate-induced protein 1|butyrate-induced transcript 1|protein tyrosine phosphatase-like A domain containing 1|protein tyrosine phosphatase-like protein PTPLAD1|protein-tyrosine phosphatase-like A domain-containing protein 1|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
Swissprots	Q9NQA7 Q8NCB1 Q8NC86 A0PJA1 Q9P035 Q280Z3 B4DRF4 Q6PD63 Q8IUI5 Q96T12
Accessions	ABB83547 EAW77735 EAW77736 Q9P035 AF161470 AAF29085 AJ271091 CAB69070 AK027421 BAB55101 AK074857 BAC11249 AK074898 BAC11277 AK225120 AK299234 BAG61266 AL137412 BC000194 BC009056 BC011443 BC019873 AAH19873 BC035508 AAH35508 BC047685 AAH47685 BC058912 AAH58912 H21635 XM_011521664 XP_011519966 NM_016395 NP_057479
Function	Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
Tissue Specificity	Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes. {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506}.
Top Pathways	Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HSPC121 (L-14) - sc-162950 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PTPLAD1 antibody - ab80902 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PTPLAD1 antibody - ab57143 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-PTPLAD1 antibody - N-terminal - ab139063 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-HACD3 / PTPLAD1 Antibody (aa31-58, AP) - LS-C239598 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HACD3 / PTPLAD1 Antibody (aa31-58, Biotin) - LS-C239599 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HACD3 / PTPLAD1 Antibody (aa31-58, APC) - LS-C239600 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HACD3 / PTPLAD1 Antibody (aa31-58, FITC) - LS-C239601 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HACD3 / PTPLAD1 Antibody (aa31-58, PE) - LS-C239602 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HACD3 / PTPLAD1 Antibody (aa31-58, Azide-free, HRP) - LS-C248583 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HACD3 / PTPLAD1 Antibody (aa31-58) - LS-C330034 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HACD3 / PTPLAD1 Antibody (aa110-159) - LS-C81015 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HACD3 / PTPLAD1 Antibody (aa32-58) - LS-C158767 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

PTPLAD1 Antibody - NBP1-59028 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PTPLAD1 Antibody - NBP1-88597 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PTPLAD1 Antibody - H00051495-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

PTPLAD1 Antibody - H00051495-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

PTPLAD1 Antibody (5B5) - H00051495-M01 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5B5

PTPLAD1 Antibody (5B5) - H00051495-M01A from Novus Biologicals Prices $349.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 5B5

PTPLAD1 Antibody - H00051495-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Monoclonal Anti-PTPLAD1 antibody produced in mouse - WH0051495M1 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 5B5

Monoclonal Anti-PTPLAD1, (N-terminal) antibody produced in mouse - SAB1405101 from Sigma-Aldrich Prices $347.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 5B5

Anti-PTPLAD1 antibody produced in rabbit - AV47251 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PTPLAD1 antibody produced in mouse - SAB1407495 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

PTPLAD1 antibody - N-terminal region (ARP47251_P050) - ARP47251_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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