LPXN

Gene Symbol LPXN
Entrez Gene 9404
Alt Symbol LDPL
Species Human
Gene Type protein-coding
Description leupaxin
Other Description -
Swissprots Q6FI07 Q53FW6 B4DV71 B2R8B4 O60711
Accessions EAW73807 EAW73808 EAW73809 O60711 AA848029 AF062075 AAC16014 AK223165 BAD96885 AK299264 BAH12983 AK300955 BAG62583 AK301093 BAG62693 AK313306 BAG36111 BC007490 BC019035 AAH19035 BC034230 BP261314 BU688891 CR536531 CAG38768 DA363664 DQ892705 ABM83631 DQ895954 ABM86880 XM_006718750 XP_006718813 XM_011545388 XP_011543690 XM_011545389 XP_011543691 XM_011545390 XP_011543692 XM_011545391 XP_011543693 XM_011545392 XP_011543694 XM_011545393 XP_011543695 XM_011545394 XP_011543696 NM_001143995 NP_001137467 NM_001307951 NP_001294880 NM_004811 NP_004802
Function Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.
Subcellular Location Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B- cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.
Tissue Specificity Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression. {ECO:0000269|PubMed:12674328, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331}.

leupaxin (F-12) - sc-376903 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
leupaxin (F-12): sc-376903. Western blot analysis of leupaxin expression in Raji (A) and Ramos (B) whole cell lysates.

leupaxin (B-2) - sc-376820 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
leupaxin (B-2): sc-376820. Western blot analysis of leupaxin expression in Raji whole cell lysate.

leupaxin (E-12) - sc-241524 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

leupaxin (N-14) - sc-241521 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
leupaxin (N-14): sc-241521. Western blot analysis of leupaxin expression in Jurkat (A), Ramos (B) and Raji (C) whole cell lysates.

leupaxin (S-13) - sc-241522 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
leupaxin (S-13): sc-241522. Western blot analysis of leupaxin expression in non-transfected 293T: sc-117752 (A), human leupaxin transfected 293T: sc-170443 (B), Ramos (D) and Raji (E) whole cell lysates.

Anti-Leupaxin antibody - ab181621 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Leupaxin antibody (ab181621) at 0.5 µg/mlLane 1 : rat thymus tissue lysateLane 2 : Jurkat cell lysate

Anti-Leupaxin antibody - ab67571 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
ICC/IF image of ab67571 stained MALME-3M cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab67571 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- mouse (ab96879) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Leupaxin antibody - ab173520 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Leupaxin antibody (ab173520) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

Anti-Leupaxin antibody - N-terminal - ab202278 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Leupaxin antibody - N-terminal (ab202278) at 1/1000 dilutionLane 1 : PC3 cell lysateLane 2 : rat A7r5 cell lysateLane 3 : A431 cell lysate

Anti-LPXN / Leupaxin Antibody (aa115-129) - LS-C313296 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
LPXN / Leupaxin antibody. IHC(P): Mouse Spleen Tissue.

Anti-LPXN / Leupaxin Antibody (aa229-257, APC) - LS-C262115 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPXN / Leupaxin Antibody (aa229-257, AP) - LS-C262114 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPXN / Leupaxin Antibody (aa229-257, Biotin) - LS-C262117 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPXN / Leupaxin Antibody (aa229-257, FITC) - LS-C262118 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPXN / Leupaxin Antibody (aa229-257, Azide-free, HRP) - LS-C262119 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPXN / Leupaxin Antibody (aa229-257, PE) - LS-C262120 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPXN / Leupaxin Antibody - LS-C309185 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-LPXN / Leupaxin Antibody (aa228-257) - LS-C322706 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPXN / Leupaxin Antibody (C-Terminus) - LS-C345119 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of LPXN Antibody with human Jurkat Whole Cell lysate.

Anti-LPXN / Leupaxin Antibody (aa229-257) - LS-C160066 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of LPXN (arrow) using rabbit polyclonal LPXN Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the LPXN gene.

Leupaxin Antibody - NBP2-31078 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Leupaxin Antibody [NBP2-31078] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

Leupaxin Antibody - H00009404-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Leupaxin Antibody [H00009404-B01P] - Analysis of LPXN expression in transfected 293T cell line by LPXN polyclonal antibody. Lane 1: LPXN transfected lysate(42.46 KDa). Lane 2: Non-transfected lysate.

Leupaxin Antibody - 43910002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Leupaxin Polyclonal Antibody - bs-13653R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Leupaxin Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13653R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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