LPXN

Gene Symbol LPXN
Entrez Gene 9404
Alt Symbol LDPL
Species Human
Gene Type protein-coding
Description leupaxin
Other Description -
Swissprots Q6FI07 Q53FW6 B4DV71 B2R8B4 O60711
Accessions EAW73807 EAW73808 EAW73809 O60711 AA848029 AF062075 AAC16014 AK223165 BAD96885 AK299264 BAH12983 AK300955 BAG62583 AK301093 BAG62693 AK313306 BAG36111 BC007490 BC019035 AAH19035 BC034230 BP261314 BU688891 CR536531 CAG38768 DA363664 DQ892705 ABM83631 DQ895954 ABM86880 XM_006718750 XP_006718813 XM_011545388 XP_011543690 XM_011545389 XP_011543691 XM_011545390 XP_011543692 XM_011545391 XP_011543693 XM_011545392 XP_011543694 XM_011545393 XP_011543695 XM_011545394 XP_011543696 NM_001143995 NP_001137467 NM_001307951 NP_001294880 NM_004811 NP_004802
Function Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.
Subcellular Location Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B- cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.
Tissue Specificity Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression. {ECO:0000269|PubMed:12674328, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331}.

Human Leupaxin full length protein - ab152980 from Abcam

Category Protein
Source Wheat germ
Species Human
ab152980 on a 12.5% SDS-PAGE stained with Coomassie Blue.

LPXN / Leupaxin Antibody Blocking Peptide - LS-E5321 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Leupaxin Protein - H00009404-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

LPXN-Antibody-Center-Blocking-Peptide - BP17801c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Leupaxin - H00009404-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Leupaxin - H00009404-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

LPXN fusion protein - ag1845 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human Leupaxin(LPXN) - CSB-YP013068HU CSB-EP013068HU CSB-BP013068HU CSB-MP013068HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Leupaxin (N-terminal region) - LX4535 from ECM Biosciences

Category Peptide
Prices $55.00
Sizes 50 μg

Recombinant Leupaxin (LPXN) - RPC571Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

LPXN Peptide, Human - M34GP08830H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Leupaxin Recombinant Protein Antigen - NBP2-31078PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Recombinant Leupaxin (LPXN) - RPU50715 from Biomatik

Category Protein
Prices $182.00, $315.00, $482.00, $602.00
Sizes 10 µg, 50 µg, 100 µg, 200 µg
Source E.coli
Species Human

Leupaxin Recombinant Protein Antigen - NBP2-55850PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Leupaxin, Recombinant Protein - MBS2033358 from MyBioSource

Category Protein
Prices $185.00, $380.00, $585.00
Sizes 10 µg, 50 µg, 100 µg
Source Prokaryotic expression
Species Mouse

Leupaxin (LPXN), Recombinant Protein - MBS1247864 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Leupaxin (LPXN), Recombinant Protein - MBS2086811 from MyBioSource

Category Protein
Prices $160.00, $320.00, $495.00
Sizes 10 µg, 50 µg, 100 µg
Source E Coli
Species Human
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